JUND
JunD proto-oncogene, AP-1 transcription factor subunit | AP-1

The protein encoded by this intronless gene is a member of the JUN family, and a functional component of the AP1 transcription factor complex. This protein has been proposed to protect cells from p53-dependent senescence and apoptosis. Alternative translation initiation site usage results in the production of different isoforms (PMID:12105216). [provided by RefSeq, Nov 2013]

Member of: DE-4 DE-4.5 Developmental clusters: GC2
Biological processes 56 terms
DNA binding (GO:0003677)DNA-binding transcription activator activity, RNA polymerase II-specific (GO:0001228)DNA-binding transcription factor activity (GO:0003700)DNA-binding transcription factor activity, RNA polymerase II-specific (GO:0000981)DNA-binding transcription factor activity, RNA polymerase II-specific (GO:0000981)RNA polymerase II cis-regulatory region sequence-specific DNA binding (GO:0000978)RNA polymerase II cis-regulatory region sequence-specific DNA binding (GO:0000978)cellular response to fatty acid (GO:0071398)cellular response to hypoxia (GO:0071456)cellular response to polyamine macromolecule (GO:1904584)chromatin (GO:0000785)chromatin (GO:0000785)circadian rhythm (GO:0007623)double-stranded DNA binding (GO:0003690)enzyme binding (GO:0019899)epithelial cell proliferation (GO:0050673)negative regulation of cardiac muscle hypertrophy (GO:0010614)negative regulation of epithelial cell proliferation (GO:0050680)negative regulation of transcription by RNA polymerase II (GO:0000122)nuclear receptor binding (GO:0016922)nucleoplasm (GO:0005654)nucleoplasm (GO:0005654)nucleus (GO:0005634)nucleus (GO:0005634)nucleus (GO:0005634)positive regulation of macrophage activation (GO:0043032)positive regulation of peroxisome proliferator activated receptor signaling pathway (GO:0035360)positive regulation of transcription by RNA polymerase II (GO:0045944)positive regulation of transcription by RNA polymerase II (GO:0045944)positive regulation of transcription by RNA polymerase II (GO:0045944)protein binding (GO:0005515)protein-DNA complex (GO:0032993)protein-containing complex (GO:0032991)regulation of DNA-templated transcription (GO:0006355)regulation of cell cycle (GO:0051726)regulation of cell population proliferation (GO:0042127)regulation of transcription by RNA polymerase II (GO:0006357)regulation of transcription by RNA polymerase II (GO:0006357)response to cold (GO:0009409)response to forskolin (GO:1904321)response to light stimulus (GO:0009416)response to lipopolysaccharide (GO:0032496)response to mechanical stimulus (GO:0009612)response to mercury ion (GO:0046689)response to peptide hormone (GO:0043434)response to steroid hormone (GO:0048545)response to water deprivation (GO:0009414)sequence-specific DNA binding (GO:0043565)sequence-specific double-stranded DNA binding (GO:1990837)transcription by RNA polymerase II (GO:0006366)transcription cis-regulatory region binding (GO:0000976)transcription cis-regulatory region binding (GO:0000976)transcription coregulator binding (GO:0001221)transcription factor AP-1 complex (GO:0035976)transcription factor AP-1 complex (GO:0035976)transcription regulator complex (GO:0005667)
Expression (TPM)
JUND — as a Regulated Gene

TFs regulating JUND 0 TFs

Transcription factors with Perturb-seq knockdown data for JUND. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = JUND upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.

Data: Effect:
TF Mean coef Binding Outlier TF→Gene link

Elements linked to JUND

Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of JUND, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.

Accessibility Element Dist. to TSS Link type TFs
chr19:18,000,754–18,001,614 280.5 kb Distal (>10kb) Multiome 788
chr19:18,007,024–18,008,451 273.5 kb Distal (>10kb) Multiome 681
chr19:18,058,070–18,058,878 223.1 kb Distal (>10kb) Multiome 542
chr19:18,104,219–18,104,847 177.1 kb Distal (>10kb) Multiome 466
chr19:18,109,636–18,110,594 171.5 kb Distal (>10kb) Multiome 601
chr19:18,117,556–18,118,528 163.7 kb Distal (>10kb) Multiome 550
chr19:18,152,230–18,153,823 128.8 kb Distal (>10kb) Multiome 809
chr19:18,160,950–18,161,791 120.2 kb Distal (>10kb) Multiome 494
chr19:18,173,513–18,174,441 107.8 kb Distal (>10kb) Multiome 667
chr19:18,192,530–18,193,908 88.6 kb Distal (>10kb) Multiome 758
chr19:18,202,796–18,205,452 77.4 kb Distal (>10kb) Multiome 823
chr19:18,220,660–18,221,487 60.6 kb Distal (>10kb) Multiome 134
chr19:18,223,665–18,226,306 57.6 kb Distal (>10kb) Multiome 790
chr19:18,232,737–18,233,413 48.5 kb Distal (>10kb) Multiome 789
chr19:18,272,479–18,272,718 8.9 kb Proximal (<10kb) 188
chr19:18,278,462–18,282,788 174 bp At TSS Multiome 1184
chr19:18,287,827–18,288,359 6.4 kb Proximal (<10kb) Multiome 221
chr19:18,291,350–18,293,764 10.4 kb Distal (>10kb) Multiome 1026
chr19:18,322,635–18,323,493 41.6 kb Distal (>10kb) Multiome 814
chr19:18,328,417–18,328,936 47.0 kb Distal (>10kb) Multiome 488
chr19:18,339,807–18,340,160 58.3 kb Distal (>10kb) Multiome 249
chr19:18,340,428–18,341,393 58.9 kb Distal (>10kb) Multiome 747
chr19:18,373,917–18,374,961 92.9 kb Distal (>10kb) Multiome 971
chr19:18,388,239–18,388,884 107.0 kb Distal (>10kb) Multiome 910
chr19:18,416,224–18,418,189 135.0 kb Distal (>10kb) Multiome 893
chr19:18,418,296–18,420,432 137.8 kb Distal (>10kb) Multiome 773
chr19:18,428,554–18,429,777 147.5 kb Distal (>10kb) Multiome 489
chr19:18,433,114–18,434,328 152.5 kb Distal (>10kb) Multiome 446
chr19:18,436,634–18,439,166 155.6 kb Distal (>10kb) Multiome 799
chr19:18,521,058–18,522,859 240.7 kb Distal (>10kb) Multiome 849
chr19:18,543,118–18,544,249 262.1 kb Distal (>10kb) Multiome 574
chr19:18,557,570–18,558,196 276.2 kb Distal (>10kb) Multiome 738
chr19:18,571,234–18,572,258 290.1 kb Distal (>10kb) Multiome 972

Genome Browser

Genomic view of the JUND locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.

chr19:17,990,754 – 18,582,258
Proximal 1 kb Distal 10 kb Multiome HiCAR ATAC-seq RNA-seq
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