Enables mRNA 3'-UTR binding activity. Predicted to be involved in regulation of mRNA stability. Predicted to be located in P granule; cytoplasmic exosome (RNase complex); and cytosol. Predicted to be active in cytoplasm. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for CARHSP1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = CARHSP1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of CARHSP1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr16:8,588,655–8,589,263 | 279.9 kb | Distal (>10kb) Multiome | 96 | |
| chr16:8,621,400–8,622,171 | 247.0 kb | Distal (>10kb) Multiome | 736 | |
| chr16:8,660,694–8,661,275 | 207.7 kb | Distal (>10kb) Multiome HiCAR | 325 | |
| chr16:8,673,966–8,674,850 | 194.2 kb | Distal (>10kb) Multiome | 585 | |
| chr16:8,797,340–8,798,108 | 71.0 kb | Distal (>10kb) Multiome | 1028 | |
| chr16:8,831,534–8,832,572 | 36.6 kb | Distal (>10kb) Multiome | 184 | |
| chr16:8,863,607–8,864,055 | 4.7 kb | Proximal (<10kb) | 680 | |
| chr16:8,866,241–8,867,974 | 2.1 kb | Proximal (<10kb) Multiome | 680 | |
| chr16:8,868,171–8,869,530 | 338 bp | At TSS Multiome | 934 | |
| chr16:8,869,586–8,869,916 | 867 bp | At TSS | 354 | |
| chr16:8,963,706–8,964,549 | 95.3 kb | Distal (>10kb) Multiome | 663 | |
| chr16:8,965,943–8,966,445 | 97.5 kb | Distal (>10kb) Multiome | 109 | |
| chr16:9,090,006–9,092,833 | 222.7 kb | Distal (>10kb) Multiome | 1125 | |
| chr16:9,107,648–9,108,299 | 239.3 kb | Distal (>10kb) Multiome | 24 |
Genomic view of the CARHSP1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.