This gene encodes a protein that likely functions as a transcription factor. The protein, which belongs to the ZNF75 family, includes an N-terminal SCAN domain, a KRAB box, and five C2H2-type zinc finger motifs. Another functional gene belonging to this family is located on chromosome 16, while pseudogenes have been identified on chromosomes 11 and 12. Alternative splicing results in multiple transcripts variants. [provided by RefSeq, Jun 2010]
Transcription factors with Perturb-seq knockdown data for ZNF75D. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ZNF75D upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ZNF75D, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chrX:135,051,315–135,052,574 | 291.9 kb | Distal (>10kb) Multiome | 523 | |
| chrX:135,097,570–135,099,197 | 245.3 kb | Distal (>10kb) Multiome | 354 | |
| chrX:135,342,871–135,343,075 | 1.0 kb | Proximal (<10kb) | 141 | |
| chrX:135,343,574–135,345,233 | 625 bp | At TSS Multiome | 657 | |
| chrX:135,421,575–135,422,695 | 77.8 kb | Distal (>10kb) Multiome | 332 | |
| chrX:135,520,416–135,522,245 | 176.5 kb | Distal (>10kb) Multiome | 678 |
Genomic view of the ZNF75D locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.