Enables sequence-specific double-stranded DNA binding activity. Involved in positive regulation of transcription by RNA polymerase II. Located in nucleoplasm. Part of transcription factor AP-1 complex. Implicated in head and neck squamous cell carcinoma and melanoma. Biomarker of gastrointestinal system cancer (multiple); lung non-small cell carcinoma; and lymphoma (multiple). [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for JUNB. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = JUNB upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of JUNB, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr19:12,782,418–12,783,038 | 8.4 kb | Proximal (<10kb) | 699 | |
| chr19:12,789,543–12,790,654 | 830 bp | At TSS | 717 | |
| chr19:12,790,960–12,793,231 | at TSS | At TSS | 1015 | |
| chr19:12,793,340–12,794,240 | 1.9 kb | Proximal (<10kb) | 808 | |
| chr19:12,796,584–12,797,024 | 5.1 kb | Proximal (<10kb) | 479 | |
| chr19:12,801,120–12,802,290 | 9.6 kb | Proximal (<10kb) | 901 |
Genomic view of the JUNB locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.