The protein encoded by this gene is predicted to be a Kruppel C2H2-type zinc-finger protein family member. Sequence analysis predicts that the protein contains two Kruppel associated box (KRAB) boxes in the N-terminus and highly conserved zinc finger motifs at the C-terminus. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2016]
Transcription factors with Perturb-seq knockdown data for ZNF184. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ZNF184 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ZNF184, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr6:27,177,493–27,178,620 | 295.1 kb | Distal (>10kb) Multiome | 685 | |
| chr6:27,188,443–27,189,128 | 284.3 kb | Distal (>10kb) Multiome HiCAR | 398 | |
| chr6:27,214,739–27,215,257 | 258.1 kb | Distal (>10kb) Multiome | 338 | |
| chr6:27,230,181–27,230,668 | 242.6 kb | Distal (>10kb) Multiome | 624 | |
| chr6:27,250,707–27,252,203 | 221.4 kb | Distal (>10kb) Multiome | 736 | |
| chr6:27,279,529–27,280,388 | 192.8 kb | Distal (>10kb) Multiome | 560 | |
| chr6:27,290,574–27,291,026 | 182.4 kb | Distal (>10kb) Multiome | 324 | |
| chr6:27,332,775–27,333,421 | 139.9 kb | Distal (>10kb) Multiome | 657 | |
| chr6:27,374,472–27,375,425 | 97.9 kb | Distal (>10kb) Multiome | 488 | |
| chr6:27,388,369–27,389,372 | 84.3 kb | Distal (>10kb) Multiome | 997 | |
| chr6:27,472,233–27,473,587 | 74 bp | At TSS Multiome | 1052 | |
| chr6:27,478,498–27,478,620 | 5.4 kb | Proximal (<10kb) | 213 | |
| chr6:27,478,759–27,479,180 | 5.7 kb | Proximal (<10kb) Multiome | 642 | |
| chr6:27,479,324–27,480,016 | 6.5 kb | Proximal (<10kb) Multiome | 750 | |
| chr6:27,495,395–27,496,098 | 22.7 kb | Distal (>10kb) Multiome | 724 | |
| chr6:27,502,683–27,503,927 | 30.7 kb | Distal (>10kb) Multiome | 699 | |
| chr6:27,505,539–27,506,022 | 32.8 kb | Distal (>10kb) Multiome | 646 | |
| chr6:27,518,890–27,519,632 | 46.2 kb | Distal (>10kb) Multiome | 717 | |
| chr6:27,545,031–27,546,022 | 72.5 kb | Distal (>10kb) Multiome | 662 | |
| chr6:27,547,469–27,547,915 | 74.6 kb | Distal (>10kb) Multiome | 440 | |
| chr6:27,552,906–27,553,807 | 80.3 kb | Distal (>10kb) Multiome | 694 | |
| chr6:27,592,359–27,593,376 | 119.8 kb | Distal (>10kb) Multiome | 844 | |
| chr6:27,602,046–27,602,794 | 129.4 kb | Distal (>10kb) Multiome | 469 | |
| chr6:27,605,356–27,606,138 | 132.7 kb | Distal (>10kb) Multiome | 562 | |
| chr6:27,630,675–27,631,795 | 158.1 kb | Distal (>10kb) Multiome | 827 | |
| chr6:27,650,587–27,651,063 | 177.8 kb | Distal (>10kb) Multiome | 541 | |
| chr6:27,668,541–27,669,069 | 195.6 kb | Distal (>10kb) Multiome | 577 | |
| chr6:27,671,980–27,673,036 | 199.3 kb | Distal (>10kb) Multiome | 845 | |
| chr6:27,684,282–27,684,819 | 211.5 kb | Distal (>10kb) Multiome | 652 | |
| chr6:27,687,268–27,688,540 | 214.6 kb | Distal (>10kb) Multiome | 972 | |
| chr6:27,752,061–27,752,956 | 279.2 kb | Distal (>10kb) Multiome | 499 | |
| chr6:27,753,073–27,753,588 | 280.2 kb | Distal (>10kb) Multiome | 758 | |
| chr6:27,762,370–27,762,921 | 289.5 kb | Distal (>10kb) Multiome | 65 | |
| chr6:27,772,302–27,773,105 | 299.6 kb | Distal (>10kb) Multiome | 784 |
Genomic view of the ZNF184 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.