chr12:57,609,052–57,609,957

chr12 : 57,609,052 – 57,609,957

905 bp 83 TFs 20 linked genes

This 905 bp open chromatin element is linked to 20 target genes and is bound by 83 transcription factors.

Linked Genes

20 genes

Gene	Expression	Dist. to TSS	Distance	Link type
ARHGEF25		1.5 kb	Proximal	Proximity
DTX3		4.4 kb	Proximal	Proximity
ENSG00000287908		5.3 kb	Proximal	Proximity
SLC26A10P		9.6 kb	Proximal	Proximity
ENSG00000293429		9.6 kb	Proximal	Proximity
ENSG00000224713		9.7 kb	Proximal	Proximity
PIP4K2C		18.1 kb	Distal	Multiome
KIF5A		59.3 kb	Distal	Multiome
DCTN2		62.2 kb	Distal	Multiome
OS9		84.8 kb	Distal	Multiome
MBD6		88.6 kb	Distal	Multiome
MARS1		121.3 kb	Distal	Multiome
TSPAN31		135.7 kb	Distal	Multiome
CDK4		143.0 kb	Distal	Multiome+HiCAR
GLI1		149.6 kb	Distal	Multiome
METTL1		162.8 kb	Distal	Multiome
TSFM		173.4 kb	Distal	Multiome
R3HDM2		178.3 kb	Distal	Multiome
CTDSP2		237.4 kb	Distal	Multiome
SHMT2		379.6 kb	Distal	Multiome+HiCAR

Chromatin Accessibility

Genome Browser

Genomic view centred on this element. Tracks include ATAC-seq accessibility, RNA-seq expression, TF binding peaks, and element-to-gene loop arcs across the ESC → DE time course.

Transcription factors with ChIP-seq peak overlap or TOBIAS motif footprint evidence at this element.

TF Binding

83 transcription factors

ChIP breast_tumor_Male_7 GSE104399.AR.breast_tumor_Male_7 277 bp overlap

ASH2L 3 datasets

ChIP H1 ENCFF399KAM 785 bp overlap

ChIP H1 ENCFF399KAM 630 bp overlap

ChIP WA01 ENCSR850KIP.ASH2L.WA01 706 bp overlap

ChIP WA01 ENCSR000BQU.ATF2.WA01 81 bp overlap

BCOR 2 datasets

ChIP WA01 GSE104690.BCOR.WA01 317 bp overlap

ChIP WA01_RNF2-R GSE104690.BCOR.WA01_RNF2-R 505 bp overlap

ChIP HUES-64 GSE104059.BRD1.HUES-64 681 bp overlap

BRD4 6 datasets

ChIP HUVEC-C GSE60171.BRD4.HUVEC-C 288 bp overlap

ChIP K-562_DMSO GSE138084.BRD4.K-562_DMSO 193 bp overlap

ChIP K-562_iBET-BD2 GSE138084.BRD4.K-562_iBET-BD2 262 bp overlap

ChIP retina_AB1-FW15 GSE86981.BRD4.retina_AB1-FW15 346 bp overlap

ChIP retina_AB1-FW23 GSE86981.BRD4.retina_AB1-FW23 641 bp overlap

ChIP retina_AB1-RB GSE86981.BRD4.retina_AB1-RB 594 bp overlap

ChIP leiomyoma_PT886 GSE128230.CDK8.leiomyoma_PT886 81 bp overlap

CREB1 3 datasets

ChIP GM23338 ENCFF432ZEW 305 bp overlap

ChIP GM23338 ENCSR214ZAV.CREB1.GM23338 176 bp overlap

ChIP WA01 ENCSR000BSN.CREB1.WA01 121 bp overlap

CTBP2 1 dataset

ChIP WA01 ENCSR000EUO.CTBP2.WA01 905 bp overlap

CTCF 2 datasets

Motif ES_0h ES_0h-CTCF_MA0139.2 15 bp overlap

Motif ES_0h ES_0h-CTCF_MA1929.2 31 bp overlap

EGR1 5 datasets

ChIP H1 ENCFF451BLH 261 bp overlap

ChIP K-562 ENCSR000BNE.EGR1.K-562 179 bp overlap

ChIP K562 ENCFF006PJY 245 bp overlap

ChIP WA01 ENCSR000BJA.EGR1.WA01 133 bp overlap

ChIP WA01 ENCSR000BJA.EGR1.WA01 124 bp overlap

EP300 1 dataset

ChIP WA01 ENCSR000BKK.EP300.WA01 172 bp overlap

ChIP Ishikawa_DMSO_D538G_clone3 GSE132426.ESR1.Ishikawa_DMSO_D538G_clone3 221 bp overlap

ETS1 4 datasets

ChIP cardiomyocyte_D0 GSE129986.ETS1.cardiomyocyte_D0 148 bp overlap

ChIP cardiomyocyte_D0 GSE129986.ETS1.cardiomyocyte_D0 443 bp overlap

ChIP cardiomyocyte_D0 GSE129986.ETS1.cardiomyocyte_D0 100 bp overlap

ChIP hESC ENCSR534VHI.ETS1.hESC 159 bp overlap

EZH2 7 datasets

ChIP GM23338 ENCSR045YHA.EZH2.GM23338 728 bp overlap

ChIP H1 ENCFF232NZA 724 bp overlap

ChIP H1 ENCFF232NZA 905 bp overlap

ChIP SU-DHL-6 GSE134136.EZH2.SU-DHL-6 570 bp overlap

ChIP WA01 ENCSR000ASY.EZH2.WA01 168 bp overlap

ChIP keratinocyte ENCSR000ARK.EZH2.keratinocyte 178 bp overlap

ChIP keratinocyte ENCSR000ARK.EZH2.keratinocyte 292 bp overlap

FOSL1 2 datasets

ChIP H1 ENCFF920RFC 217 bp overlap

ChIP WA01 ENCSR000BNS.FOSL1.WA01 193 bp overlap

FOXP1 1 dataset

ChIP WTC11 ENCFF338WGC 525 bp overlap

GATA2 1 dataset

ChIP K-562 ENCSR000DKA.GATA2.K-562 296 bp overlap

GLIS1 1 dataset

ChIP HEK293 ENCSR482BBZ.GLIS1.HEK293 284 bp overlap

GLIS2 2 datasets

ChIP HEK293 ENCFF446EIF 511 bp overlap

ChIP HEK293 ENCSR535DIA.GLIS2.HEK293 400 bp overlap

GLIS3 1 dataset

ChIP H9_plus GSE109562.GLIS3.H9_plus 457 bp overlap

HDAC2 3 datasets

ChIP K-562 ENCSR893WSB.HDAC2.K-562 208 bp overlap

ChIP WA01 ENCSR000AVB.HDAC2.WA01 314 bp overlap

ChIP WA01 ENCSR000AVB.HDAC2.WA01 68 bp overlap

HDGF 2 datasets

ChIP K-562 ENCSR197ALX.HDGF.K-562 551 bp overlap

ChIP K-562 ENCSR563YDA.HDGF.K-562 371 bp overlap

JARID2 1 dataset

ChIP MRC-5_IPS25_MEG3 GSE48515.JARID2.MRC-5_IPS25_MEG3 347 bp overlap

ChIP ESC S34-ESC-d0-JUN-exp2 487 bp overlap

KDM4A 4 datasets

ChIP H1 ENCFF078LED 673 bp overlap

ChIP H1 ENCFF078LED 674 bp overlap

ChIP WA01 ENCSR000AVC.KDM4A.WA01 164 bp overlap

ChIP WA01 ENCSR000AVC.KDM4A.WA01 210 bp overlap

KLF17 2 datasets

ChIP HEK293 ENCFF658MHR 425 bp overlap

ChIP HEK293 ENCSR065WUF.KLF17.HEK293 432 bp overlap

KLF4 2 datasets

ChIP BJ_INDUCED GSE36570.KLF4.BJ_INDUCED 133 bp overlap

ChIP hiPSC GSE56567.KLF4.hiPSC 147 bp overlap

KLF5 2 datasets

Motif ES_0h ES_0h-KLF5_MA0599.1 10 bp overlap

ChIP HEK293_E419Q GSE88976.KLF5.HEK293_E419Q 431 bp overlap

ChIP CCRF-CEM GSE33850.LMO2.CCRF-CEM 236 bp overlap

ChIP WTC11 ENCFF223QFY 506 bp overlap

ChIP HEK293 ENCFF994GSG 221 bp overlap

ChIP HEK293 ENCSR290SSQ.MAZ.HEK293 393 bp overlap

ChIP K-562 ENCSR000EFX.MAZ.K-562 111 bp overlap

ChIP P493-6_scramble-shRNA GSE101853.MYC.P493-6_scramble-shRNA 174 bp overlap

NANOG 3 datasets

ChIP HUES-8 GSE109524.NANOG.HUES-8 378 bp overlap

ChIP HUES-8 GSE109524.NANOG.HUES-8 98 bp overlap

ChIP WA01 ENCSR000BMT.NANOG.WA01 117 bp overlap

NFRKB 3 datasets

ChIP K-562 ENCSR657EOF.NFRKB.K-562 349 bp overlap

ChIP K562 ENCFF057YFW 591 bp overlap

ChIP K562 ENCFF057YFW 582 bp overlap

NIPBL 3 datasets

ChIP hESC GSE64758.NIPBL.hESC 236 bp overlap

ChIP hESC_WNT3A_ACTIVIN GSE64758.NIPBL.hESC_WNT3A_ACTIVIN 224 bp overlap

ChIP hESC_WNT3A_ACTIVIN GSE64758.NIPBL.hESC_WNT3A_ACTIVIN 57 bp overlap

NR2F2 1 dataset

ChIP K-562 ENCSR000BRS.NR2F2.K-562 235 bp overlap

PATZ1 2 datasets

ChIP HEK293 ENCFF016MNJ 521 bp overlap

ChIP HEK293 ENCSR966ULI.PATZ1.HEK293 286 bp overlap

ChIP myometrium_NP1 GSE137550.PGR.myometrium_NP1 55 bp overlap

POLR2A 2 datasets

ChIP GM23338 ENCFF450WCS 491 bp overlap

ChIP K562 ENCFF215CWW 677 bp overlap

POU5F1 2 datasets

ChIP DE_D1 DED1-OCT4_Batch_II 788 bp overlap

ChIP HUES-8 GSE109524.POU5F1.HUES-8 283 bp overlap

POU5F1_M 1 dataset

ChIP DE_D1 DED1-OCT4-M_Batch_II 418 bp overlap

Prdm4 1 dataset

Motif ES_0h ES_0h-Prdm4_MA1647.3 11 bp overlap

RBBP5 1 dataset

ChIP WA01 ENCSR000AQC.RBBP5.WA01 225 bp overlap

RBFOX2 2 datasets

ChIP K-562 ENCSR822LBD.RBFOX2.K-562 221 bp overlap

ChIP K-562 GSE120104.RBFOX2.K-562 184 bp overlap

RNF2 3 datasets

ChIP HUES-64 GSE104059.RNF2.HUES-64 292 bp overlap

ChIP WA01 GSE104690.RNF2.WA01 286 bp overlap

ChIP WA01 ENCSR784VUY.RNF2.WA01 539 bp overlap

ChIP WA01 GSE104690.RYBP.WA01 373 bp overlap

SAP30 1 dataset

ChIP WA01 ENCSR000ATR.SAP30.WA01 170 bp overlap

SETDB1 1 dataset

ChIP K-562 ENCSR000EWI.SETDB1.K-562 176 bp overlap

SIN3A 7 datasets

ChIP H1 ENCFF042ZSL 482 bp overlap

ChIP H1 ENCFF042ZSL 79 bp overlap

ChIP H1 ENCFF896IJG 139 bp overlap

ChIP WA01 ENCSR000EBO.SIN3A.WA01 199 bp overlap

ChIP WA01 ENCSR000BIS.SIN3A.WA01 145 bp overlap

ChIP WA01 ENCSR000EBO.SIN3A.WA01 141 bp overlap

ChIP WA01 ENCSR000BIS.SIN3A.WA01 71 bp overlap

SMAD2-3 3 datasets

ChIP HUES-8_DE_JNKi GSE109524.SMAD2-3.HUES-8_DE_JNKi 393 bp overlap

ChIP HUES-8_DE_ctrl GSE109524.SMAD2-3.HUES-8_DE_ctrl 390 bp overlap

ChIP HUVEC-C_TGFB1 GSE134556.SMAD2-3.HUVEC-C_TGFB1 577 bp overlap

SMAD2_3 2 datasets

ChIP DE_D1 S39-DE-d1-SMAD2_3-exp2 358 bp overlap

ChIP DE_D2 S01-DE-d2-SMAD2_3-exp1 285 bp overlap

SMARCA4 2 datasets

ChIP K-562 ENCSR643VTW.SMARCA4.K-562 291 bp overlap

ChIP hiPSC_WT GSE124903.SMARCA4.hiPSC_WT 169 bp overlap

SMARCB1 1 dataset

ChIP hiPSC_WT GSE124903.SMARCB1.hiPSC_WT 175 bp overlap

SMARCE1 1 dataset

ChIP K-562 ENCSR157TCS.SMARCE1.K-562 244 bp overlap

SNRNP70 1 dataset

ChIP K-562 ENCSR754ZHU.SNRNP70.K-562 220 bp overlap

ChIP hiPSC GSE56567.SOX2.hiPSC 178 bp overlap

ChIP H1 ENCFF263FUH 321 bp overlap

ChIP WA01 ENCSR000BIR.SP1.WA01 218 bp overlap

ChIP HEK293 ENCFF181QXT 485 bp overlap

Motif ES_0h ES_0h-SP3_MA0746.3 11 bp overlap

ChIP WA01 ENCSR000BQV.SP4.WA01 226 bp overlap

SUZ12 3 datasets

ChIP WA01 ENCSR000ATS.SUZ12.WA01 208 bp overlap

ChIP WA01 ENCSR000ATS.SUZ12.WA01 119 bp overlap

ChIP hiPSC_WT GSE124903.SUZ12.hiPSC_WT 159 bp overlap

ChIP K-562 ENCSR000BKS.TAF1.K-562 338 bp overlap

ChIP PRIMA2 GSE33850.TAL1.PRIMA2 189 bp overlap

TARDBP 1 dataset

ChIP K-562 ENCSR429XTR.TARDBP.K-562 318 bp overlap

ChIP K-562 GSE55306.TBP.K-562 267 bp overlap

ChIP hESC_2h GSE122298.TBP.hESC_2h 164 bp overlap

TCF12 2 datasets

ChIP H1 ENCFF203EBH 251 bp overlap

ChIP WA01 ENCSR000BIT.TCF12.WA01 162 bp overlap

TFAP2C 1 dataset

ChIP UCLA1-hESCs_TFAP2C--_1d_TFAP2C_Induc GSE101074.TFAP2C.UCLA1-hESCs_TFAP2C--_1d_TFAP2C_Induc 327 bp overlap

TP53 2 datasets

ChIP WTC11 ENCFF359JCU 488 bp overlap

ChIP WTC11 ENCFF359JCU 537 bp overlap

TRIM28 1 dataset

ChIP hESC GSE115387.TRIM28.hESC 207 bp overlap

ChIP WTC11 ENCFF699QGS 366 bp overlap

ChIP WTC11 ENCFF139JAW 417 bp overlap

ChIP HEK293 ENCFF906HIR 425 bp overlap

ChIP HEK293 ENCSR966PJJ.WT1.HEK293 275 bp overlap

XRCC5 1 dataset

ChIP K-562 GSE120104.XRCC5.K-562 146 bp overlap

ChIP K-562 ENCSR000BMH.YY1.K-562 155 bp overlap

ChIP K-562 ENCSR000BMH.YY1.K-562 165 bp overlap

ChIP K562 ENCFF660QRE 311 bp overlap

ChIP WA01 ENCSR000BKD.YY1.WA01 294 bp overlap

ChIP WA01 ENCSR000BKD.YY1.WA01 277 bp overlap

ZBTB7A 6 datasets

ChIP K-562 GSE103445.ZBTB7A.K-562 183 bp overlap

ChIP K-562 ENCSR000BME.ZBTB7A.K-562 531 bp overlap

ChIP K-562 GSE103445.ZBTB7A.K-562 222 bp overlap

ChIP K-562 ENCSR000BME.ZBTB7A.K-562 91 bp overlap

ChIP K562 ENCFF579ZGM 401 bp overlap

ChIP K562 ENCFF579ZGM 401 bp overlap

ZNF143 2 datasets

ChIP WA01 ENCSR000EBW.ZNF143.WA01 184 bp overlap

ChIP WA01 ENCSR000EBW.ZNF143.WA01 101 bp overlap

ZNF148 6 datasets

ChIP K-562 ENCSR018MSO.ZNF148.K-562 356 bp overlap

ChIP K-562 GSE121133.ZNF148.K-562 256 bp overlap

ChIP K-562 ENCSR018MSO.ZNF148.K-562 310 bp overlap

ChIP K-562 GSE121133.ZNF148.K-562 266 bp overlap

ChIP K562 ENCFF352SDL 574 bp overlap

ChIP K562 ENCFF352SDL 505 bp overlap

ZNF281 4 datasets

ChIP K-562 GSE121133.ZNF281.K-562 503 bp overlap

ChIP K-562 GSE121133.ZNF281.K-562 225 bp overlap

ChIP K562 ENCFF594VNM 471 bp overlap

ChIP WTC11 ENCFF551GAV 377 bp overlap

ZNF467 1 dataset

ChIP HEK293 GSE76494.ZNF467.HEK293 147 bp overlap

ZNF534 1 dataset

ChIP HEK293T GSE78099.ZNF534.HEK293T 147 bp overlap

ZNF592 1 dataset

ChIP K-562 ENCSR249BHQ.ZNF592.K-562 359 bp overlap

ZNF600 1 dataset

ChIP HEK293 ENCFF785JSX 491 bp overlap