Enables protease binding activity. Involved in several processes, including chromatin remodeling; regulation of chromosome organization; and regulation of nucleobase-containing compound metabolic process. Located in Ino80 complex and nucleoplasm. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for NFRKB. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = NFRKB upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of NFRKB, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr11:129,695,611–129,696,567 | 199.6 kb | Distal (>10kb) Multiome | 266 | |
| chr11:129,750,339–129,751,168 | 144.7 kb | Distal (>10kb) Multiome | 421 | |
| chr11:129,815,544–129,816,526 | 79.6 kb | Distal (>10kb) Multiome | 315 | |
| chr11:129,894,845–129,896,318 | 43 bp | At TSS Multiome | 678 | |
| chr11:130,001,573–130,003,849 | 107.2 kb | Distal (>10kb) Multiome | 1080 | |
| chr11:130,068,597–130,071,216 | 174.2 kb | Distal (>10kb) Multiome | 898 | |
| chr11:130,076,579–130,077,560 | 181.5 kb | Distal (>10kb) Multiome | 129 | |
| chr11:130,146,013–130,146,727 | 250.9 kb | Distal (>10kb) Multiome HiCAR | 413 | |
| chr11:130,159,259–130,160,341 | 264.3 kb | Distal (>10kb) Multiome | 309 |
Genomic view of the NFRKB locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.