Enables U1 snRNA binding activity. Involved in mRNA splicing, via spliceosome and regulation of RNA splicing. Located in nucleoplasm. Part of U1 snRNP and spliceosomal complex. Implicated in disease of mental health and systemic lupus erythematosus. Biomarker of Alzheimer's disease. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for SNRNP70. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = SNRNP70 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of SNRNP70, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr19:48,795,165–48,795,736 | 289.9 kb | Distal (>10kb) Multiome | 724 | |
| chr19:48,806,734–48,807,478 | 278.5 kb | Distal (>10kb) Multiome | 452 | |
| chr19:48,810,774–48,811,494 | 274.4 kb | Distal (>10kb) Multiome | 662 | |
| chr19:48,812,048–48,813,099 | 272.9 kb | Distal (>10kb) Multiome | 603 | |
| chr19:48,829,998–48,830,690 | 255.1 kb | Distal (>10kb) Multiome | 55 | |
| chr19:48,835,571–48,838,073 | 249.6 kb | Distal (>10kb) Multiome | 621 | |
| chr19:48,872,000–48,873,835 | 213.1 kb | Distal (>10kb) Multiome | 987 | |
| chr19:48,895,958–48,896,628 | 189.1 kb | Distal (>10kb) Multiome | 207 | |
| chr19:48,899,782–48,900,620 | 185.2 kb | Distal (>10kb) Multiome | 710 | |
| chr19:48,933,397–48,933,948 | 151.8 kb | Distal (>10kb) Multiome | 458 | |
| chr19:48,954,440–48,955,356 | 130.6 kb | Distal (>10kb) Multiome | 905 | |
| chr19:48,963,322–48,964,187 | 121.6 kb | Distal (>10kb) Multiome | 866 | |
| chr19:48,964,515–48,966,446 | 120.2 kb | Distal (>10kb) Multiome | 1015 | |
| chr19:48,992,571–48,994,129 | 91.9 kb | Distal (>10kb) Multiome | 852 | |
| chr19:49,017,642–49,018,292 | 67.5 kb | Distal (>10kb) Multiome | 480 | |
| chr19:49,019,277–49,019,889 | 65.8 kb | Distal (>10kb) Multiome | 233 | |
| chr19:49,055,975–49,056,714 | 29.2 kb | Distal (>10kb) Multiome | 431 | |
| chr19:49,064,668–49,065,682 | 20.3 kb | Distal (>10kb) Multiome | 226 | |
| chr19:49,071,761–49,072,903 | 13.4 kb | Distal (>10kb) Multiome | 278 | |
| chr19:49,084,646–49,086,115 | 82 bp | At TSS Multiome | 1030 | |
| chr19:49,113,727–49,115,240 | 29.6 kb | Distal (>10kb) Multiome | 746 | |
| chr19:49,118,477–49,120,300 | 33.7 kb | Distal (>10kb) Multiome | 949 | |
| chr19:49,127,647–49,128,949 | 42.7 kb | Distal (>10kb) Multiome | 1000 | |
| chr19:49,129,106–49,129,678 | 44.2 kb | Distal (>10kb) Multiome | 197 | |
| chr19:49,132,975–49,134,197 | 48.1 kb | Distal (>10kb) Multiome | 179 | |
| chr19:49,142,781–49,143,252 | 57.6 kb | Distal (>10kb) Multiome | 299 | |
| chr19:49,145,727–49,146,720 | 60.8 kb | Distal (>10kb) Multiome | 511 | |
| chr19:49,148,659–49,150,947 | 65.2 kb | Distal (>10kb) Multiome | 917 | |
| chr19:49,151,539–49,152,548 | 66.6 kb | Distal (>10kb) Multiome | 497 | |
| chr19:49,157,555–49,158,336 | 72.4 kb | Distal (>10kb) Multiome | 599 | |
| chr19:49,210,032–49,211,225 | 125.1 kb | Distal (>10kb) Multiome | 366 | |
| chr19:49,337,997–49,340,482 | 253.8 kb | Distal (>10kb) Multiome | 612 | |
| chr19:49,361,283–49,362,837 | 276.2 kb | Distal (>10kb) Multiome | 553 | |
| chr19:49,362,970–49,364,306 | 278.3 kb | Distal (>10kb) Multiome | 616 |
Genomic view of the SNRNP70 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.