DTX3 functions as an E3 ubiquitin ligase (Takeyama et al., 2003 [PubMed 12670957]).[supplied by OMIM, Nov 2009]
Transcription factors with Perturb-seq knockdown data for DTX3. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = DTX3 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of DTX3, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr12:57,224,526–57,225,152 | 379.6 kb | Distal (>10kb) Multiome HiCAR | 267 | |
| chr12:57,225,987–57,227,617 | 377.5 kb | Distal (>10kb) Multiome HiCAR | 236 | |
| chr12:57,229,358–57,230,407 | 374.7 kb | Distal (>10kb) Multiome HiCAR | 739 | |
| chr12:57,377,252–57,378,039 | 226.9 kb | Distal (>10kb) Multiome | 170 | |
| chr12:57,430,384–57,431,415 | 173.6 kb | Distal (>10kb) Multiome | 879 | |
| chr12:57,454,516–57,456,639 | 148.3 kb | Distal (>10kb) Multiome | 841 | |
| chr12:57,458,743–57,463,318 | 143.3 kb | Distal (>10kb) Multiome | 994 | |
| chr12:57,475,229–57,476,151 | 129.1 kb | Distal (>10kb) Multiome | 194 | |
| chr12:57,487,577–57,488,336 | 116.7 kb | Distal (>10kb) Multiome | 784 | |
| chr12:57,519,488–57,521,440 | 83.9 kb | Distal (>10kb) Multiome | 1029 | |
| chr12:57,521,541–57,523,658 | 81.9 kb | Distal (>10kb) Multiome | 960 | |
| chr12:57,546,771–57,547,419 | 57.4 kb | Distal (>10kb) Multiome | 623 | |
| chr12:57,549,654–57,550,343 | 54.6 kb | Distal (>10kb) Multiome | 366 | |
| chr12:57,583,383–57,583,948 | 21.1 kb | Distal (>10kb) Multiome | 353 | |
| chr12:57,590,813–57,591,877 | 13.4 kb | Distal (>10kb) Multiome HiCAR | 738 | |
| chr12:57,604,466–57,605,404 | 216 bp | At TSS Multiome | 337 | |
| chr12:57,605,566–57,605,777 | 945 bp | At TSS | 63 | |
| chr12:57,609,052–57,609,957 | 4.7 kb | Proximal (<10kb) Multiome | 83 | |
| chr12:57,610,841–57,611,876 | 6.8 kb | Proximal (<10kb) Multiome | 558 | |
| chr12:57,614,300–57,614,474 | 9.7 kb | Proximal (<10kb) | 101 | |
| chr12:57,621,603–57,622,199 | 17.3 kb | Distal (>10kb) Multiome | 446 | |
| chr12:57,631,837–57,633,369 | 28.5 kb | Distal (>10kb) Multiome | 706 | |
| chr12:57,693,486–57,694,647 | 89.4 kb | Distal (>10kb) Multiome | 757 | |
| chr12:57,726,079–57,726,879 | 121.7 kb | Distal (>10kb) Multiome | 597 | |
| chr12:57,738,612–57,739,176 | 134.4 kb | Distal (>10kb) Multiome HiCAR | 201 | |
| chr12:57,744,434–57,745,735 | 140.4 kb | Distal (>10kb) Multiome | 822 | |
| chr12:57,751,806–57,753,147 | 147.9 kb | Distal (>10kb) Multiome | 1030 | |
| chr12:57,754,455–57,756,188 | 150.3 kb | Distal (>10kb) Multiome | 616 | |
| chr12:57,756,649–57,757,193 | 152.3 kb | Distal (>10kb) Multiome HiCAR | 315 | |
| chr12:57,765,020–57,765,720 | 160.7 kb | Distal (>10kb) Multiome | 472 | |
| chr12:57,766,452–57,767,514 | 162.4 kb | Distal (>10kb) Multiome | 330 | |
| chr12:57,771,528–57,773,018 | 167.5 kb | Distal (>10kb) Multiome | 1006 | |
| chr12:57,782,579–57,783,204 | 178.1 kb | Distal (>10kb) Multiome | 916 | |
| chr12:57,814,980–57,815,520 | 210.7 kb | Distal (>10kb) Multiome | 117 | |
| chr12:57,844,422–57,847,797 | 242.4 kb | Distal (>10kb) Multiome | 1032 | |
| chr12:57,852,281–57,853,469 | 248.2 kb | Distal (>10kb) Multiome | 295 | |
| chr12:57,865,060–57,865,767 | 260.8 kb | Distal (>10kb) Multiome | 547 | |
| chr12:57,888,522–57,889,064 | 284.0 kb | Distal (>10kb) Multiome | 328 | |
| chr12:57,896,473–57,897,915 | 292.3 kb | Distal (>10kb) Multiome | 419 |
Genomic view of the DTX3 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.