Enables 1-phosphatidylinositol-4-phosphate 5-kinase activity and identical protein binding activity. Involved in 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate biosynthetic process; negative regulation of insulin receptor signaling pathway; and positive regulation of autophagosome assembly. Located in several cellular components, including autophagosome; cytosol; and nucleoplasm. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for PIP4K2C. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = PIP4K2C upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of PIP4K2C, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr12:57,377,252–57,378,039 | 213.5 kb | Distal (>10kb) Multiome | 170 | |
| chr12:57,430,384–57,431,415 | 160.2 kb | Distal (>10kb) Multiome | 879 | |
| chr12:57,454,516–57,456,639 | 134.9 kb | Distal (>10kb) Multiome | 841 | |
| chr12:57,458,743–57,463,318 | 129.8 kb | Distal (>10kb) Multiome | 994 | |
| chr12:57,475,229–57,476,151 | 115.6 kb | Distal (>10kb) Multiome | 194 | |
| chr12:57,487,577–57,488,336 | 103.3 kb | Distal (>10kb) Multiome | 784 | |
| chr12:57,519,488–57,521,440 | 70.5 kb | Distal (>10kb) Multiome | 1029 | |
| chr12:57,521,541–57,523,658 | 68.5 kb | Distal (>10kb) Multiome | 960 | |
| chr12:57,546,771–57,547,419 | 44.0 kb | Distal (>10kb) Multiome | 623 | |
| chr12:57,549,654–57,550,343 | 41.2 kb | Distal (>10kb) Multiome | 366 | |
| chr12:57,583,383–57,583,948 | 7.7 kb | Proximal (<10kb) Multiome | 353 | |
| chr12:57,590,813–57,591,877 | 30 bp | At TSS Multiome | 738 | |
| chr12:57,604,466–57,605,404 | 13.6 kb | Distal (>10kb) Multiome | 337 | |
| chr12:57,609,052–57,609,957 | 18.1 kb | Distal (>10kb) Multiome | 83 | |
| chr12:57,610,841–57,611,876 | 20.3 kb | Distal (>10kb) Multiome HiCAR | 558 | |
| chr12:57,621,603–57,622,199 | 30.7 kb | Distal (>10kb) Multiome HiCAR | 446 | |
| chr12:57,631,837–57,633,369 | 41.9 kb | Distal (>10kb) Multiome | 706 | |
| chr12:57,693,486–57,694,647 | 102.8 kb | Distal (>10kb) Multiome | 757 | |
| chr12:57,726,079–57,726,879 | 135.1 kb | Distal (>10kb) Multiome | 597 | |
| chr12:57,738,612–57,739,176 | 147.8 kb | Distal (>10kb) Multiome HiCAR | 201 | |
| chr12:57,744,434–57,745,735 | 153.8 kb | Distal (>10kb) Multiome | 822 | |
| chr12:57,751,806–57,753,147 | 161.3 kb | Distal (>10kb) Multiome | 1030 | |
| chr12:57,754,455–57,756,188 | 163.7 kb | Distal (>10kb) Multiome | 616 | |
| chr12:57,756,649–57,757,193 | 165.8 kb | Distal (>10kb) Multiome | 315 | |
| chr12:57,765,020–57,765,720 | 174.2 kb | Distal (>10kb) Multiome | 472 | |
| chr12:57,766,452–57,767,514 | 175.9 kb | Distal (>10kb) Multiome | 330 | |
| chr12:57,771,528–57,773,018 | 180.9 kb | Distal (>10kb) Multiome | 1006 | |
| chr12:57,782,579–57,783,204 | 191.6 kb | Distal (>10kb) Multiome | 916 | |
| chr12:57,814,980–57,815,520 | 224.1 kb | Distal (>10kb) Multiome | 117 | |
| chr12:57,844,422–57,847,797 | 255.8 kb | Distal (>10kb) Multiome | 1032 | |
| chr12:57,852,281–57,853,469 | 261.7 kb | Distal (>10kb) Multiome | 295 | |
| chr12:57,865,060–57,865,767 | 274.2 kb | Distal (>10kb) Multiome | 547 | |
| chr12:57,888,522–57,889,064 | 297.4 kb | Distal (>10kb) Multiome | 328 |
Genomic view of the PIP4K2C locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.