Transcription factors with Perturb-seq knockdown data for ENSG00000224713. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ENSG00000224713 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ENSG00000224713, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr12:57,609,052–57,609,957 | 9.7 kb | Proximal (<10kb) | 83 | |
| chr12:57,610,841–57,611,876 | 7.8 kb | Proximal (<10kb) | 558 | |
| chr12:57,614,300–57,614,474 | 5.2 kb | Proximal (<10kb) | 101 | |
| chr12:57,619,368–57,619,897 | at TSS | At TSS | 197 | |
| chr12:57,621,603–57,622,199 | 2.0 kb | Proximal (<10kb) | 446 | |
| chr12:57,627,535–57,628,303 | 7.9 kb | Proximal (<10kb) | 115 |
Genomic view of the ENSG00000224713 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.