Enables chromatin binding activity. Located in chromocenter; fibrillar center; and nucleoplasm. Implicated in autism spectrum disorder. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for MBD6. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = MBD6 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of MBD6, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr12:57,224,526–57,225,152 | 295.7 kb | Distal (>10kb) Multiome | 267 | |
| chr12:57,225,987–57,227,617 | 293.6 kb | Distal (>10kb) Multiome | 236 | |
| chr12:57,229,358–57,230,407 | 290.9 kb | Distal (>10kb) Multiome | 739 | |
| chr12:57,237,805–57,241,749 | 281.5 kb | Distal (>10kb) Multiome | 846 | |
| chr12:57,242,371–57,244,402 | 276.9 kb | Distal (>10kb) Multiome | 596 | |
| chr12:57,270,778–57,271,413 | 249.6 kb | Distal (>10kb) Multiome | 155 | |
| chr12:57,272,508–57,273,156 | 247.9 kb | Distal (>10kb) Multiome | 98 | |
| chr12:57,377,252–57,378,039 | 143.0 kb | Distal (>10kb) Multiome | 170 | |
| chr12:57,430,384–57,431,415 | 89.7 kb | Distal (>10kb) Multiome | 879 | |
| chr12:57,454,516–57,456,639 | 64.4 kb | Distal (>10kb) Multiome | 841 | |
| chr12:57,458,743–57,463,318 | 59.3 kb | Distal (>10kb) Multiome | 994 | |
| chr12:57,475,229–57,476,151 | 45.1 kb | Distal (>10kb) Multiome | 194 | |
| chr12:57,487,577–57,488,336 | 32.8 kb | Distal (>10kb) Multiome | 784 | |
| chr12:57,519,488–57,521,440 | 27 bp | At TSS Multiome | 1029 | |
| chr12:57,521,541–57,523,658 | 2.0 kb | Proximal (<10kb) Multiome | 960 | |
| chr12:57,546,771–57,547,419 | 26.5 kb | Distal (>10kb) Multiome HiCAR | 623 | |
| chr12:57,549,654–57,550,343 | 29.3 kb | Distal (>10kb) Multiome HiCAR | 366 | |
| chr12:57,583,383–57,583,948 | 62.8 kb | Distal (>10kb) Multiome | 353 | |
| chr12:57,590,813–57,591,877 | 70.5 kb | Distal (>10kb) Multiome | 738 | |
| chr12:57,604,466–57,605,404 | 84.1 kb | Distal (>10kb) Multiome | 337 | |
| chr12:57,609,052–57,609,957 | 88.6 kb | Distal (>10kb) Multiome | 83 | |
| chr12:57,610,841–57,611,876 | 90.7 kb | Distal (>10kb) Multiome | 558 | |
| chr12:57,621,603–57,622,199 | 101.2 kb | Distal (>10kb) Multiome | 446 | |
| chr12:57,631,837–57,633,369 | 112.4 kb | Distal (>10kb) Multiome | 706 | |
| chr12:57,693,486–57,694,647 | 173.3 kb | Distal (>10kb) Multiome | 757 | |
| chr12:57,726,079–57,726,879 | 205.6 kb | Distal (>10kb) Multiome | 597 | |
| chr12:57,738,612–57,739,176 | 218.3 kb | Distal (>10kb) Multiome | 201 | |
| chr12:57,744,434–57,745,735 | 224.3 kb | Distal (>10kb) Multiome | 822 | |
| chr12:57,751,806–57,753,147 | 231.8 kb | Distal (>10kb) Multiome | 1030 | |
| chr12:57,754,455–57,756,188 | 234.2 kb | Distal (>10kb) Multiome | 616 | |
| chr12:57,756,649–57,757,193 | 236.3 kb | Distal (>10kb) Multiome | 315 | |
| chr12:57,765,020–57,765,720 | 244.7 kb | Distal (>10kb) Multiome | 472 | |
| chr12:57,766,452–57,767,514 | 246.4 kb | Distal (>10kb) Multiome | 330 | |
| chr12:57,771,528–57,773,018 | 251.4 kb | Distal (>10kb) Multiome | 1006 | |
| chr12:57,782,579–57,783,204 | 262.1 kb | Distal (>10kb) Multiome | 916 | |
| chr12:57,814,980–57,815,520 | 294.6 kb | Distal (>10kb) Multiome | 117 |
Genomic view of the MBD6 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.