The protein encoded by this gene is part of the large ATP-dependent chromatin remodeling complex SWI/SNF, which is required for transcriptional activation of genes normally repressed by chromatin. The encoded protein, either alone or when in the SWI/SNF complex, can bind to 4-way junction DNA, which is thought to mimic the topology of DNA as it enters or exits the nucleosome. The protein contains a DNA-binding HMG domain, but disruption of this domain does not abolish the DNA-binding or nucleosome-displacement activities of the SWI/SNF complex. Unlike most of the SWI/SNF complex proteins, this protein has no yeast counterpart. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for SMARCE1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = SMARCE1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of SMARCE1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr17:40,362,469–40,363,831 | 285.0 kb | Distal (>10kb) Multiome | 846 | |
| chr17:40,417,289–40,418,494 | 229.8 kb | Distal (>10kb) Multiome | 793 | |
| chr17:40,422,953–40,423,555 | 224.6 kb | Distal (>10kb) Multiome | 242 | |
| chr17:40,442,866–40,444,146 | 204.4 kb | Distal (>10kb) Multiome | 774 | |
| chr17:40,483,550–40,484,556 | 163.9 kb | Distal (>10kb) Multiome | 84 | |
| chr17:40,499,140–40,499,767 | 148.3 kb | Distal (>10kb) Multiome | 358 | |
| chr17:40,615,478–40,615,916 | 32.1 kb | Distal (>10kb) Multiome | 297 | |
| chr17:40,637,853–40,638,362 | 9.7 kb | Proximal (<10kb) Multiome | 83 | |
| chr17:40,638,473–40,638,606 | 9.2 kb | Proximal (<10kb) | 8 | |
| chr17:40,647,363–40,647,898 | at TSS | At TSS | 741 | |
| chr17:40,648,009–40,648,408 | 167 bp | At TSS | 842 | |
| chr17:40,735,202–40,736,205 | 87.8 kb | Distal (>10kb) Multiome | 21 | |
| chr17:41,662,549–41,663,015 | 1015.0 kb | Distal (>10kb) Multiome HiCAR | 643 | |
| chr17:41,665,564–41,667,291 | 1019.4 kb | Distal (>10kb) Multiome HiCAR | 883 |
Genomic view of the SMARCE1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.