HDGF

heparin binding growth factor | HMG1L2

This gene encodes a member of the hepatoma-derived growth factor family. The encoded protein has mitogenic and DNA-binding activity and may play a role in cellular proliferation and differentiation. High levels of expression of this gene enhance the growth of many tumors. This gene was thought initially to be located on chromosome X; however, that location has been determined to correspond to a related pseudogene. Alternatively spliced transcript variants encoding distinct isoforms have been described. [provided by RefSeq, Jan 2016]

Member of: DE-4 Developmental clusters: GC6

Biological processes 32 terms

DNA-binding transcription repressor activity, RNA polymerase II-specific (GO:0001227)RNA binding (GO:0003723)RNA polymerase II cis-regulatory region sequence-specific DNA binding (GO:0000978)actin binding (GO:0003779)chromatin remodeling (GO:0006338)cytoplasm (GO:0005737)cytoplasm (GO:0005737)cytoplasm (GO:0005737)extracellular region (GO:0005576)extracellular region (GO:0005576)extracellular region (GO:0005576)extracellular region (GO:0005576)heparin binding (GO:0008201)heparin binding (GO:0008201)heparin binding (GO:0008201)negative regulation of transcription by RNA polymerase II (GO:0000122)negative regulation of transcription by RNA polymerase II (GO:0000122)nucleoplasm (GO:0005654)nucleoplasm (GO:0005654)nucleus (GO:0005634)nucleus (GO:0005634)nucleus (GO:0005634)positive regulation of cell division (GO:0051781)positive regulation of cell division (GO:0051781)positive regulation of transcription by RNA polymerase II (GO:0045944)protein binding (GO:0005515)protein localization to nucleus (GO:0034504)signal transduction (GO:0007165)transcription corepressor activity (GO:0003714)transcription corepressor binding (GO:0001222)transcription repressor complex (GO:0017053)tubulin binding (GO:0015631)

Expression (TPM)

TFs regulating HDGF 0 TFs

Transcription factors with Perturb-seq knockdown data for HDGF. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = HDGF upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.

TF	Mean coef	Binding	Outlier	TF→Gene link

Rows:

Elements linked to HDGF

Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of HDGF, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.

Element	Dist. to TSS	Link type	TFs
chr1:156,456,348–156,457,982	295.7 kb	Distal (>10kb) Multiome	1033
chr1:156,499,927–156,501,599	251.5 kb	Distal (>10kb) Multiome	950
chr1:156,504,626–156,505,685	247.1 kb	Distal (>10kb) Multiome	911
chr1:156,572,298–156,572,749	179.9 kb	Distal (>10kb) Multiome	580
chr1:156,583,883–156,584,356	168.4 kb	Distal (>10kb) Multiome	183
chr1:156,591,252–156,592,285	160.7 kb	Distal (>10kb) Multiome	706
chr1:156,601,188–156,601,796	150.9 kb	Distal (>10kb) Multiome	759
chr1:156,624,123–156,624,848	127.9 kb	Distal (>10kb) Multiome	472
chr1:156,641,772–156,642,623	110.4 kb	Distal (>10kb) Multiome	211
chr1:156,657,279–156,657,727	94.9 kb	Distal (>10kb) Multiome	357
chr1:156,659,788–156,660,816	92.2 kb	Distal (>10kb) Multiome	901
chr1:156,673,575–156,674,145	78.6 kb	Distal (>10kb) Multiome	269
chr1:156,676,488–156,677,779	75.1 kb	Distal (>10kb) Multiome	449
chr1:156,689,084–156,690,144	62.8 kb	Distal (>10kb) Multiome	508
chr1:156,692,653–156,693,825	59.3 kb	Distal (>10kb) Multiome	493
chr1:156,703,427–156,704,626	48.5 kb	Distal (>10kb) Multiome	182
chr1:156,704,839–156,707,238	46.3 kb	Distal (>10kb) Multiome	728
chr1:156,708,331–156,708,813	44.0 kb	Distal (>10kb) Multiome	108
chr1:156,728,152–156,729,282	23.7 kb	Distal (>10kb) Multiome	815
chr1:156,740,482–156,741,987	11.2 kb	Distal (>10kb) Multiome	1012
chr1:156,746,390–156,748,386	5.2 kb	Proximal (<10kb) Multiome	750
chr1:156,751,012–156,752,594	612 bp	At TSS Multiome	869
chr1:156,766,695–156,768,280	14.9 kb	Distal (>10kb) Multiome	967
chr1:156,813,606–156,814,470	61.6 kb	Distal (>10kb) Multiome	756
chr1:156,845,268–156,845,794	93.1 kb	Distal (>10kb) Multiome	73
chr1:156,848,614–156,849,138	96.5 kb	Distal (>10kb) Multiome	129
chr1:156,860,147–156,861,294	108.2 kb	Distal (>10kb) Multiome	484
chr1:156,862,753–156,863,585	110.8 kb	Distal (>10kb) Multiome	268
chr1:156,892,162–156,892,597	140.0 kb	Distal (>10kb) Multiome	439
chr1:156,893,409–156,893,975	141.4 kb	Distal (>10kb) Multiome	143
chr1:156,920,128–156,921,047	168.1 kb	Distal (>10kb) Multiome	508
chr1:156,927,257–156,928,255	175.4 kb	Distal (>10kb) Multiome	424
chr1:156,996,881–156,997,694	244.9 kb	Distal (>10kb) Multiome	167
chr1:157,045,268–157,046,656	293.5 kb	Distal (>10kb) Multiome	678

Genome Browser

Genomic view of the HDGF locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.