Enables RNA binding activity. Predicted to be located in nucleus. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for R3HDM2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = R3HDM2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of R3HDM2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr12:57,214,315–57,214,722 | 216.4 kb | Distal (>10kb) Multiome | 318 | |
| chr12:57,215,826–57,217,972 | 214.3 kb | Distal (>10kb) Multiome | 525 | |
| chr12:57,219,094–57,219,803 | 211.5 kb | Distal (>10kb) Multiome | 71 | |
| chr12:57,224,526–57,225,152 | 206.0 kb | Distal (>10kb) Multiome | 267 | |
| chr12:57,225,987–57,227,617 | 203.9 kb | Distal (>10kb) Multiome | 236 | |
| chr12:57,229,358–57,230,407 | 201.2 kb | Distal (>10kb) Multiome | 739 | |
| chr12:57,237,805–57,241,749 | 191.8 kb | Distal (>10kb) Multiome | 846 | |
| chr12:57,242,371–57,244,402 | 187.2 kb | Distal (>10kb) Multiome | 596 | |
| chr12:57,270,778–57,271,413 | 159.9 kb | Distal (>10kb) Multiome | 155 | |
| chr12:57,272,508–57,273,156 | 158.2 kb | Distal (>10kb) Multiome | 98 | |
| chr12:57,377,252–57,378,039 | 53.3 kb | Distal (>10kb) Multiome | 170 | |
| chr12:57,430,384–57,431,415 | 20 bp | At TSS Multiome | 879 | |
| chr12:57,454,516–57,456,639 | 25.3 kb | Distal (>10kb) Multiome | 841 | |
| chr12:57,458,743–57,463,318 | 30.4 kb | Distal (>10kb) Multiome | 994 | |
| chr12:57,475,229–57,476,151 | 44.6 kb | Distal (>10kb) Multiome | 194 | |
| chr12:57,487,577–57,488,336 | 56.9 kb | Distal (>10kb) Multiome | 784 | |
| chr12:57,519,488–57,521,440 | 89.7 kb | Distal (>10kb) Multiome | 1029 | |
| chr12:57,521,541–57,523,658 | 91.7 kb | Distal (>10kb) Multiome | 960 | |
| chr12:57,546,771–57,547,419 | 116.2 kb | Distal (>10kb) Multiome | 623 | |
| chr12:57,549,654–57,550,343 | 119.0 kb | Distal (>10kb) Multiome | 366 | |
| chr12:57,583,383–57,583,948 | 152.5 kb | Distal (>10kb) Multiome | 353 | |
| chr12:57,590,813–57,591,877 | 160.2 kb | Distal (>10kb) Multiome | 738 | |
| chr12:57,604,466–57,605,404 | 173.8 kb | Distal (>10kb) Multiome | 337 | |
| chr12:57,609,052–57,609,957 | 178.3 kb | Distal (>10kb) Multiome | 83 | |
| chr12:57,610,841–57,611,876 | 180.5 kb | Distal (>10kb) Multiome | 558 | |
| chr12:57,621,603–57,622,199 | 190.9 kb | Distal (>10kb) Multiome | 446 | |
| chr12:57,631,837–57,633,369 | 202.1 kb | Distal (>10kb) Multiome | 706 | |
| chr12:57,693,486–57,694,647 | 263.0 kb | Distal (>10kb) Multiome | 757 | |
| chr12:57,726,079–57,726,879 | 295.3 kb | Distal (>10kb) Multiome | 597 |
Genomic view of the R3HDM2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.