This gene encodes a member of the steroid thyroid hormone superfamily of nuclear receptors. The encoded protein is a ligand inducible transcription factor that is involved in the regulation of many different genes. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Mar 2010]
Transcription factors with Perturb-seq knockdown data for NR2F2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = NR2F2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of NR2F2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr15:96,320,741–96,321,108 | 9.6 kb | Proximal (<10kb) | 43 | |
| chr15:96,321,379–96,321,734 | 9.0 kb | Proximal (<10kb) | 103 | |
| chr15:96,321,791–96,323,544 | 7.2 kb | Proximal (<10kb) | 273 | |
| chr15:96,326,041–96,326,246 | 4.5 kb | Proximal (<10kb) | 237 | |
| chr15:96,326,757–96,327,751 | 2.9 kb | Proximal (<10kb) | 494 | |
| chr15:96,330,032–96,331,709 | at TSS | At TSS | 726 | |
| chr15:96,331,916–96,332,821 | 1.2 kb | Proximal (<10kb) | 485 | |
| chr15:96,333,124–96,334,854 | 2.4 kb | Proximal (<10kb) | 435 | |
| chr15:96,340,380–96,344,000 | 9.7 kb | Proximal (<10kb) | 513 |
Genomic view of the NR2F2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.