Histone acetylation plays a key role in the regulation of eukaryotic gene expression. Histone acetylation and deacetylation are catalyzed by multisubunit complexes. The protein encoded by this gene is a component of the histone deacetylase complex, which includes SIN3, SAP18, HDAC1, HDAC2, RbAp46, RbAp48, and other polypeptides. This complex is active in deacetylating core histone octamers, but inactive in deacetylating nucleosomal histones. A pseudogene of this gene is located on chromosome 3. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for SAP30. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = SAP30 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of SAP30, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr4:173,073,972–173,074,966 | 296.4 kb | Distal (>10kb) Multiome | 454 | |
| chr4:173,167,923–173,170,542 | 201.1 kb | Distal (>10kb) Multiome | 816 | |
| chr4:173,333,360–173,335,855 | 35.5 kb | Distal (>10kb) Multiome | 1085 | |
| chr4:173,369,270–173,372,372 | 31 bp | At TSS Multiome | 989 | |
| chr4:173,448,962–173,449,725 | 78.4 kb | Distal (>10kb) Multiome | 186 | |
| chr4:173,494,018–173,494,859 | 123.6 kb | Distal (>10kb) Multiome | 388 | |
| chr4:173,521,529–173,524,247 | 151.6 kb | Distal (>10kb) Multiome | 413 | |
| chr4:173,526,721–173,528,011 | 156.5 kb | Distal (>10kb) Multiome | 247 | |
| chr4:173,608,292–173,609,220 | 237.8 kb | Distal (>10kb) Multiome | 219 |
Genomic view of the SAP30 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.