chr7:74,282,776–74,283,619

chr7 : 74,282,776 – 74,283,619

843 bp 157 TFs 6 linked genes

This 843 bp open chromatin element is linked to 6 target genes and is bound by 157 transcription factors.

Linked Genes

6 genes

Gene	Expression	Dist. to TSS	Distance	Link type
ENSG00000287815		5.7 kb	Proximal	Proximity
CLIP2		5.8 kb	Proximal	Proximity
RFC2		28.6 kb	Distal	Multiome+HiCAR
EIF4H		108.7 kb	Distal	Multiome
GTF2IRD1		170.7 kb	Distal	Multiome
LIMK1		199.1 kb	Distal	Multiome

Chromatin Accessibility

Genome Browser

Genomic view centred on this element. Tracks include ATAC-seq accessibility, RNA-seq expression, TF binding peaks, and element-to-gene loop arcs across the ESC → DE time course.

Transcription factors with ChIP-seq peak overlap or TOBIAS motif footprint evidence at this element.

TF Binding

157 transcription factors

Motif DE_72h DE_72h-ALX3_MA0634.2 6 bp overlap

ASH2L 1 dataset

ChIP WA01 ENCSR850KIP.ASH2L.WA01 415 bp overlap

ChIP WA01 ENCSR000BQU.ATF2.WA01 200 bp overlap

BCL11A 3 datasets

ChIP H1 ENCFF833IPY 145 bp overlap

ChIP WA01 ENCSR000BIP.BCL11A.WA01 209 bp overlap

ChIP WA01 ENCSR000BMJ.BCL11A.WA01 162 bp overlap

BCOR 2 datasets

ChIP WA01_RNF2-R GSE104690.BCOR.WA01_RNF2-R 149 bp overlap

ChIP WA01_RNF2-R_Doxycyclin GSE104690.BCOR.WA01_RNF2-R_Doxycyclin 253 bp overlap

ChIP MV4-11_IBET151_500nM GSE120715.BRD2.MV4-11_IBET151_500nM 146 bp overlap

BRD4 5 datasets

ChIP COLO-741 GSE73319.BRD4.COLO-741 259 bp overlap

ChIP HEK293T GSE51633.BRD4.HEK293T 135 bp overlap

ChIP MV4-11_IBET151_50nM GSE120715.BRD4.MV4-11_IBET151_50nM 160 bp overlap

ChIP retina_AB1-FW15 GSE86981.BRD4.retina_AB1-FW15 486 bp overlap

ChIP retina_AB1-FW23 GSE86981.BRD4.retina_AB1-FW23 265 bp overlap

ChIP WA01 ENCSR000EBT.CHD2.WA01 216 bp overlap

CHD4 2 datasets

ChIP RH5 GSE155861.CHD4.RH5 220 bp overlap

ChIP SCMC GSE155861.CHD4.SCMC 650 bp overlap

ChIP hiPSC_derived_lt-NES GSE108506.CHD7.hiPSC_derived_lt-NES 225 bp overlap

CREB1 1 dataset

ChIP WA01 ENCSR000BSN.CREB1.WA01 158 bp overlap

Cebpa 1 dataset

ChIP BLaER1 ENCFF364PUR 331 bp overlap

Motif DE_72h DE_72h-DRGX_MA1481.2 6 bp overlap

Motif DE_72h DE_72h-Dlx2_MA0885.3 8 bp overlap

Motif DE_72h DE_72h-Dlx5_MA1476.3 8 bp overlap

E2F6 2 datasets

ChIP H1 ENCFF785DWK 451 bp overlap

ChIP WA01 ENCSR000BSI.E2F6.WA01 219 bp overlap

Motif DE_72h DE_72h-EMX1_MA0612.3 6 bp overlap

Motif DE_72h DE_72h-EMX2_MA0886.2 6 bp overlap

Motif DE_72h DE_72h-EN1_MA0027.3 6 bp overlap

Motif DE_72h DE_72h-EN2_MA0642.3 7 bp overlap

EOMES 2 datasets

ChIP hESC GSE26097.EOMES.hESC 286 bp overlap

ChIP hESC GSE26097.EOMES.hESC 182 bp overlap

EP300 2 datasets

ChIP Ishikawa ENCSR000BUE.EP300.Ishikawa 267 bp overlap

ChIP WA01 ENCSR000BKK.EP300.WA01 203 bp overlap

ESR1 9 datasets

ChIP Ishikawa ENCSR000BIY.ESR1.Ishikawa 161 bp overlap

ChIP Ishikawa ENCSR000BKL.ESR1.Ishikawa 184 bp overlap

ChIP Ishikawa ENCSR000BQR.ESR1.Ishikawa 192 bp overlap

ChIP Ishikawa_C2-14 GSE147141.ESR1.Ishikawa_C2-14 236 bp overlap

ChIP Ishikawa_DMSO_D538G_clone3 GSE132426.ESR1.Ishikawa_DMSO_D538G_clone3 376 bp overlap

ChIP Ishikawa_E2_D538G_clone2 GSE132426.ESR1.Ishikawa_E2_D538G_clone2 368 bp overlap

ChIP Ishikawa_ETV4-KO2_Mili GSE129803.ESR1.Ishikawa_ETV4-KO2_Mili 302 bp overlap

ChIP Ishikawa_siETV4-72h GSE129803.ESR1.Ishikawa_siETV4-72h 300 bp overlap

ChIP Ishikawa_siNTC-72h GSE129803.ESR1.Ishikawa_siNTC-72h 311 bp overlap

Motif DE_72h DE_72h-ESX1_MA0644.3 7 bp overlap

Motif DE_72h DE_72h-EVX1_MA0887.2 6 bp overlap

Motif DE_72h DE_72h-EVX2_MA0888.2 6 bp overlap

EZH1 2 datasets

ChIP ProEs GSE59087.EZH1.ProEs 164 bp overlap

ChIP ProEs_SHCTR GSE59087.EZH1.ProEs_SHCTR 132 bp overlap

FOXA1 1 dataset

ChIP Ishikawa ENCSR000BKW.FOXA1.Ishikawa 165 bp overlap

FOXA2 2 datasets

ChIP DE DE-FOXA2-1 423 bp overlap

ChIP DE DE-FOXA2-2 473 bp overlap

FOXD2 1 dataset

Motif DE_72h DE_72h-FOXD2_MA0847.4 11 bp overlap

FOXD3 1 dataset

Motif DE_72h DE_72h-FOXD3_MA0041.3 14 bp overlap

FOXE1 1 dataset

Motif DE_72h DE_72h-FOXE1_MA1487.3 12 bp overlap

FOXO1-PAX3 2 datasets

ChIP RH4_DMSO-6H GSE116344.FOXO1-PAX3.RH4_DMSO-6H 192 bp overlap

ChIP RH4_Entinostat-6H GSE116344.FOXO1-PAX3.RH4_Entinostat-6H 202 bp overlap

FOXP4 1 dataset

ChIP WTC11 ENCFF708TAF 377 bp overlap

GATA4 2 datasets

ChIP DE DE-GATA4-1 319 bp overlap

ChIP DE DE-GATA4-2 350 bp overlap

GATA6 3 datasets

ChIP DE DE-GATA6-1 296 bp overlap

ChIP DE DE-GATA6-1 285 bp overlap

ChIP DE DE-GATA6-2 368 bp overlap

Motif DE_72h DE_72h-GBX1_MA0889.2 7 bp overlap

GLIS1 2 datasets

ChIP HEK293 ENCFF299RSE 244 bp overlap

ChIP HEK293 ENCSR482BBZ.GLIS1.HEK293 327 bp overlap

GLIS2 1 dataset

Motif DE_72h DE_72h-GLIS2_MA0736.1 14 bp overlap

GLIS3 2 datasets

Motif DE_72h DE_72h-GLIS3_MA0737.1 14 bp overlap

ChIP H9_plus GSE109562.GLIS3.H9_plus 592 bp overlap

Motif DE_72h DE_72h-GSX1_MA0892.2 6 bp overlap

Motif DE_72h DE_72h-GSX2_MA0893.3 7 bp overlap

GTF3C2 1 dataset

ChIP H9 GSE94418.GTF3C2.H9 414 bp overlap

HDAC2 3 datasets

ChIP H1 ENCFF939VKA 237 bp overlap

ChIP WA01 ENCSR000AVB.HDAC2.WA01 184 bp overlap

ChIP WA01 ENCSR000BNR.HDAC2.WA01 188 bp overlap

Motif DE_72h DE_72h-HIC2_MA0738.2 6 bp overlap

HOXA1 1 dataset

Motif DE_72h DE_72h-HOXA1_MA1495.2 6 bp overlap

HOXA2 1 dataset

Motif DE_72h DE_72h-HOXA2_MA0900.3 6 bp overlap

HOXA3 1 dataset

Motif DE_72h DE_72h-HOXA3_MA2119.1 7 bp overlap

HOXA5 1 dataset

Motif DE_72h DE_72h-HOXA5_MA0158.2 8 bp overlap

HOXA6 1 dataset

Motif DE_72h DE_72h-HOXA6_MA1497.2 7 bp overlap

HOXB1 1 dataset

Motif DE_72h DE_72h-HOXB1_MA2093.1 7 bp overlap

HOXB2 1 dataset

Motif DE_72h DE_72h-HOXB2_MA0902.3 6 bp overlap

HOXB3 1 dataset

Motif DE_72h DE_72h-HOXB3_MA0903.2 6 bp overlap

HOXB5 1 dataset

Motif DE_72h DE_72h-HOXB5_MA0904.3 6 bp overlap

HOXB6 1 dataset

Motif DE_72h DE_72h-HOXB6_MA1500.2 7 bp overlap

HOXB7 1 dataset

Motif DE_72h DE_72h-HOXB7_MA1501.2 7 bp overlap

HOXB8 1 dataset

Motif DE_72h DE_72h-HOXB8_MA1502.2 7 bp overlap

HOXC8 1 dataset

Motif DE_72h DE_72h-HOXC8_MA1505.2 6 bp overlap

HOXD3 1 dataset

Motif DE_72h DE_72h-HOXD3_MA0912.2 8 bp overlap

HOXD8 1 dataset

Motif DE_72h DE_72h-HOXD8_MA0910.3 7 bp overlap

INSM1 1 dataset

Motif DE_72h DE_72h-INSM1_MA0155.1 12 bp overlap

Motif DE_72h DE_72h-ISX_MA0654.2 6 bp overlap

JARID2 1 dataset

ChIP MRC-5_IPS25_MEG3 GSE48515.JARID2.MRC-5_IPS25_MEG3 207 bp overlap

ChIP DE_D1 S08-DE-d1-JUN-exp1 381 bp overlap

ChIP DE_D2 S02-DE-d2-JUN-exp1 424 bp overlap

ChIP HUES-8_DE_ctrl GSE109524.JUN.HUES-8_DE_ctrl 442 bp overlap

ChIP WA01 ENCSR000EBZ.JUND.WA01 154 bp overlap

KDM1A 3 datasets

ChIP H1 ENCFF696SGD 278 bp overlap

ChIP NB4_DMSO GSE128528.KDM1A.NB4_DMSO 308 bp overlap

ChIP pancreatic-progenitor_PP1 GSE104840.KDM1A.pancreatic-progenitor_PP1 229 bp overlap

ChIP HEK293_D418N GSE88976.KLF5.HEK293_D418N 168 bp overlap

Motif DE_72h DE_72h-LBX1_MA0618.2 7 bp overlap

Motif DE_72h DE_72h-LHX5_MA1519.2 7 bp overlap

Motif DE_72h DE_72h-LHX6_MA0658.2 8 bp overlap

Motif DE_72h DE_72h-LHX9_MA0701.3 7 bp overlap

LMX1A 1 dataset

Motif DE_72h DE_72h-LMX1A_MA0702.3 7 bp overlap

LMX1B 1 dataset

Motif DE_72h DE_72h-LMX1B_MA0703.3 8 bp overlap

Motif DE_72h DE_72h-Lhx1_MA1518.3 10 bp overlap

Motif DE_72h DE_72h-Lhx4_MA0704.2 6 bp overlap

Motif DE_72h DE_72h-Lhx8_MA0705.2 6 bp overlap

ChIP Ishikawa ENCSR000BTY.MAX.Ishikawa 152 bp overlap

ChIP HUVEC-C_siCTL GSE124892.MED1.HUVEC-C_siCTL 601 bp overlap

MEOX1 1 dataset

Motif DE_72h DE_72h-MEOX1_MA0661.2 7 bp overlap

MEOX2 1 dataset

Motif DE_72h DE_72h-MEOX2_MA0706.2 7 bp overlap

MIXL1 1 dataset

Motif DE_72h DE_72h-MIXL1_MA0662.2 6 bp overlap

MLLT1 1 dataset

ChIP GM12878 ENCSR552XSN.MLLT1.GM12878 290 bp overlap

Motif DE_72h DE_72h-MNX1_MA0707.3 6 bp overlap

ChIP WA01 ENCSR000EBR.MXI1.WA01 151 bp overlap

MYOD1 1 dataset

ChIP rhabdomyosarcoma GSE50413.MYOD1.rhabdomyosarcoma 160 bp overlap

NANOG 7 datasets

ChIP H1 ENCFF747ZPQ 241 bp overlap

ChIP HUES-8 GSE109524.NANOG.HUES-8 332 bp overlap

ChIP WA01 ENCSR000BMT.NANOG.WA01 254 bp overlap

ChIP WA01_3IL ERP004238.NANOG.WA01_3IL 222 bp overlap

ChIP WA09 GSE105028.NANOG.WA09 342 bp overlap

ChIP WA09_heat-shock GSE105028.NANOG.WA09_heat-shock 314 bp overlap

ChIP hESC GSE18292.NANOG.hESC 96 bp overlap

NCOA1 1 dataset

ChIP MCF-7 ERP000901.NCOA1.MCF-7 126 bp overlap

NFE2 2 datasets

ChIP K-562 ENCSR552YGL.NFE2.K-562 311 bp overlap

ChIP K562 ENCFF047YKA 405 bp overlap

NKX6-2 1 dataset

Motif DE_72h DE_72h-NKX6-2_MA0675.2 6 bp overlap

Motif DE_72h DE_72h-NOTO_MA0710.2 7 bp overlap

NR3C1 1 dataset

ChIP Ishikawa ENCSR000BJC.NR3C1.Ishikawa 214 bp overlap

Nr2e3 1 dataset

Motif DE_72h DE_72h-Nr2e3_MA0164.2 6 bp overlap

OLIG2 1 dataset

ChIP brain-prefrontal-cortex_2018006 GSE129039.OLIG2.brain-prefrontal-cortex_2018006 238 bp overlap

ChIP WTC11 ENCFF634NAO 206 bp overlap

Motif DE_72h DE_72h-PAX4_MA0068.2 8 bp overlap

Motif DE_72h DE_72h-PDX1_MA0132.3 6 bp overlap

POU5F1 2 datasets

ChIP DE_D1 DED1-OCT4_Batch_II 289 bp overlap

ChIP WA01 ENCSR000BMU.POU5F1.WA01 148 bp overlap

POU5F1_M 1 dataset

ChIP DE_D1 DED1-OCT4-M_Batch_II 309 bp overlap

POU6F1 1 dataset

Motif DE_72h DE_72h-POU6F1_MA0628.2 6 bp overlap

POU6F2 1 dataset

Motif DE_72h DE_72h-POU6F2_MA0793.2 9 bp overlap

PRRX1 1 dataset

Motif DE_72h DE_72h-PRRX1_MA0716.2 6 bp overlap

PRRX2 1 dataset

Motif DE_72h DE_72h-PRRX2_MA0075.4 7 bp overlap

Motif DE_72h DE_72h-RAX2_MA0717.2 6 bp overlap

RBBP4 1 dataset

ChIP SCMC GSE155861.RBBP4.SCMC 488 bp overlap

RBM25 1 dataset

ChIP K-562 ENCSR791OZM.RBM25.K-562 246 bp overlap

ChIP 786-O GSE86092.RELA.786-O 260 bp overlap

Motif DE_72h DE_72h-REST_MA0138.3 20 bp overlap

Motif DE_72h DE_72h-SHOX_MA0630.2 6 bp overlap

SIN3A 1 dataset

ChIP WA01 ENCSR000EBO.SIN3A.WA01 163 bp overlap

SMAD2 2 datasets

ChIP endoderm GSE29422.SMAD2.endoderm 300 bp overlap

ChIP endoderm GSE29422.SMAD2.endoderm 222 bp overlap

SMAD2-3 3 datasets

ChIP HUES-8_DE GSE109524.SMAD2-3.HUES-8_DE 843 bp overlap

ChIP HUES-8_DE_JNKi GSE109524.SMAD2-3.HUES-8_DE_JNKi 520 bp overlap

ChIP HUES-8_DE_ctrl GSE109524.SMAD2-3.HUES-8_DE_ctrl 685 bp overlap

SMAD2_3 5 datasets

ChIP DE_D1 S07-DE-d1-SMAD2_3-exp1 554 bp overlap

ChIP DE_D1 S12-DE-d1-SMAD2_3-exp1 426 bp overlap

ChIP DE_D1 S39-DE-d1-SMAD2_3-exp2 553 bp overlap

ChIP DE_D2 S01-DE-d2-SMAD2_3-exp1 843 bp overlap

ChIP DE_D2 S53-DE-d2-SMAD2_3-exp2 832 bp overlap

SMAD3 5 datasets

ChIP BG03_DIFF_2H GSE36578.SMAD3.BG03_DIFF_2H 170 bp overlap

ChIP BG03_DIFF_48H GSE36578.SMAD3.BG03_DIFF_48H 243 bp overlap

ChIP endoderm GSE29422.SMAD3.endoderm 337 bp overlap

ChIP endoderm GSE29422.SMAD3.endoderm 197 bp overlap

ChIP hESC GSE29422.SMAD3.hESC 152 bp overlap

SMAD4 2 datasets

ChIP endoderm GSE29422.SMAD4.endoderm 349 bp overlap

ChIP endoderm GSE29422.SMAD4.endoderm 249 bp overlap

SMARCA4 3 datasets

ChIP NSC GSE125033.SMARCA4.NSC 221 bp overlap

ChIP hiPSC GSE124903.SMARCA4.hiPSC 268 bp overlap

ChIP hiPSC_WT GSE124903.SMARCA4.hiPSC_WT 326 bp overlap

SMARCB1 1 dataset

ChIP hiPSC GSE124903.SMARCB1.hiPSC 221 bp overlap

SMARCC1 1 dataset

ChIP hiPSC GSE124903.SMARCC1.hiPSC 217 bp overlap

SOX17 1 dataset

ChIP DE_D2 DED2-SOX17_Batch_II 256 bp overlap

SOX17_M 1 dataset

ChIP DE_D2 DED2-SOX17-M_Batch_II 224 bp overlap

ChIP H1 ENCFF263FUH 291 bp overlap

ChIP WA01 ENCSR000BIR.SP1.WA01 259 bp overlap

ChIP WA01 ENCSR000BQV.SP4.WA01 162 bp overlap

SREBP2 1 dataset

ChIP monocyte_TNF GSE129202.SREBP2.monocyte_TNF 209 bp overlap

Shox2 1 dataset

Motif DE_72h DE_72h-Shox2_MA0720.2 6 bp overlap

ChIP H9_ENDODERM GSE60606.T.H9_ENDODERM 231 bp overlap

ChIP H9_MESODERM GSE60606.T.H9_MESODERM 369 bp overlap

ChIP WA01 ENCSR000BHO.TAF1.WA01 147 bp overlap

TAF15 1 dataset

ChIP K-562 ENCSR047LSJ.TAF15.K-562 241 bp overlap

ChIP WA01 ENCSR000ECB.TBP.WA01 164 bp overlap

TBX5 3 datasets

ChIP G296S_4 GSE85628.TBX5.G296S_4 234 bp overlap

ChIP G296S_4 GSE85628.TBX5.G296S_4 403 bp overlap

ChIP cardiomyocyte_5 GSE85628.TBX5.cardiomyocyte_5 225 bp overlap

TCF12 2 datasets

ChIP Ishikawa ENCSR000BUV.TCF12.Ishikawa 153 bp overlap

ChIP WA01 ENCSR000BIT.TCF12.WA01 187 bp overlap

TEAD1 2 datasets

ChIP WTC11 ENCFF502QUV 322 bp overlap

ChIP WTC11 ENCFF502QUV 405 bp overlap

TEAD4 4 datasets

ChIP H1 ENCFF778PAX 245 bp overlap

ChIP Ishikawa ENCFF772OTG 254 bp overlap

ChIP Ishikawa ENCSR000BSW.TEAD4.Ishikawa 202 bp overlap

ChIP WTC11 ENCFF114TZS 314 bp overlap

Motif DE_72h DE_72h-TLX2_MA1577.2 6 bp overlap

ChIP hESC_DAMAGED GSE39912.TP53.hESC_DAMAGED 210 bp overlap

TP63 3 datasets

ChIP SUIT-2 GSE115461.TP63.SUIT-2 273 bp overlap

ChIP breast-organoid GSE113909.TP63.breast-organoid 116 bp overlap

ChIP keratinocyte_diff GSE33571.TP63.keratinocyte_diff 141 bp overlap

Motif DE_72h DE_72h-UNCX_MA0721.2 6 bp overlap

Motif DE_72h DE_72h-VAX1_MA0722.2 7 bp overlap

Motif DE_72h DE_72h-VAX2_MA0723.3 6 bp overlap

Motif DE_72h DE_72h-VSX1_MA0725.2 7 bp overlap

Motif DE_72h DE_72h-VSX2_MA0726.2 7 bp overlap

ChIP GM12892 ENCSR000BLT.YY1.GM12892 129 bp overlap

ZBTB24 1 dataset

Motif DE_72h DE_72h-ZBTB24_MA2330.1 10 bp overlap

ZBTB5 1 dataset

ChIP K-562 ENCSR389PWB.ZBTB5.K-562 273 bp overlap

ZBTB7A 1 dataset

ChIP Ishikawa ENCSR000BSZ.ZBTB7A.Ishikawa 138 bp overlap

ZFP36 5 datasets

ChIP A-549 ENCSR294JWV.ZFP36.A-549 194 bp overlap

ChIP A549 ENCFF505LUC 291 bp overlap

ChIP GM12878 ENCFF234WRG 297 bp overlap

ChIP GM12878 ENCSR900XDB.ZFP36.GM12878 269 bp overlap

ChIP K-562 ENCSR776CYN.ZFP36.K-562 163 bp overlap

ChIP HEK293 ENCFF033NQQ 269 bp overlap

Motif DE_72h DE_72h-ZIC4_MA0751.2 14 bp overlap

Motif DE_72h DE_72h-ZIC5_MA1584.2 15 bp overlap

ZKSCAN1 2 datasets

ChIP Hep-G2 ENCSR157CAU.ZKSCAN1.Hep-G2 213 bp overlap

ChIP HepG2 ENCFF578KDY 308 bp overlap

ZMYM3 3 datasets

ChIP GM12878 GSE97661.ZMYM3.GM12878 286 bp overlap

ChIP Hep-G2_Ab_JH39-2-2F10 GSE97661.ZMYM3.Hep-G2_Ab_JH39-2-2F10 142 bp overlap

ChIP K-562 ENCSR102KIN.ZMYM3.K-562 177 bp overlap

ZNF121 1 dataset

ChIP WTC11 ENCFF291API 297 bp overlap

ZNF142 1 dataset

ChIP Hep-G2 ENCSR512ECF.ZNF142.Hep-G2 139 bp overlap

ZNF143 2 datasets

ChIP FLP143HA_T4 GSE39263.ZNF143.FLP143HA_T4 146 bp overlap

ChIP WA01 ENCSR000EBW.ZNF143.WA01 143 bp overlap

ZNF16 2 datasets

ChIP HEK293 ENCFF231FLW 153 bp overlap

ChIP HEK293 ENCSR093HXE.ZNF16.HEK293 358 bp overlap

ChIP K-562 ENCSR195QFV.ZNF3.K-562 310 bp overlap

ZNF407 1 dataset

ChIP Hep-G2 ENCSR005WGY.ZNF407.Hep-G2 183 bp overlap

ZNF423 1 dataset

ChIP WTC11 ENCFF574PBR 284 bp overlap

ZNF92 1 dataset

ChIP retina_pigment GSE60024.ZNF92.retina_pigment 284 bp overlap