EZH1 is a component of a noncanonical Polycomb repressive complex-2 (PRC2) that mediates methylation of histone H3 (see MIM 602812) lys27 (H3K27) and functions in the maintenance of embryonic stem cell pluripotency and plasticity (Shen et al., 2008 [PubMed 19026780]).[supplied by OMIM, Mar 2009]
Transcription factors with Perturb-seq knockdown data for EZH1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = EZH1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of EZH1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr17:42,531,503–42,532,256 | 213.1 kb | Distal (>10kb) Multiome | 571 | |
| chr17:42,535,863–42,536,855 | 208.7 kb | Distal (>10kb) Multiome | 987 | |
| chr17:42,547,934–42,548,909 | 196.6 kb | Distal (>10kb) Multiome | 325 | |
| chr17:42,554,285–42,555,164 | 190.2 kb | Distal (>10kb) Multiome | 899 | |
| chr17:42,561,770–42,562,376 | 182.9 kb | Distal (>10kb) Multiome | 905 | |
| chr17:42,566,552–42,567,732 | 178.0 kb | Distal (>10kb) Multiome | 902 | |
| chr17:42,577,421–42,578,281 | 167.2 kb | Distal (>10kb) Multiome | 884 | |
| chr17:42,578,382–42,578,892 | 166.3 kb | Distal (>10kb) Multiome | 477 | |
| chr17:42,608,764–42,610,335 | 135.5 kb | Distal (>10kb) Multiome | 909 | |
| chr17:42,658,938–42,659,852 | 85.7 kb | Distal (>10kb) Multiome | 734 | |
| chr17:42,669,472–42,671,112 | 74.3 kb | Distal (>10kb) Multiome | 230 | |
| chr17:42,673,584–42,674,462 | 71.0 kb | Distal (>10kb) Multiome | 296 | |
| chr17:42,674,847–42,675,579 | 69.8 kb | Distal (>10kb) Multiome | 194 | |
| chr17:42,676,055–42,678,790 | 67.9 kb | Distal (>10kb) Multiome | 1070 | |
| chr17:42,679,005–42,680,519 | 65.1 kb | Distal (>10kb) Multiome | 654 | |
| chr17:42,682,736–42,683,400 | 62.3 kb | Distal (>10kb) Multiome | 480 | |
| chr17:42,743,695–42,743,902 | 1.1 kb | Proximal (<10kb) | 132 | |
| chr17:42,744,352–42,745,375 | 78 bp | At TSS Multiome | 966 | |
| chr17:42,761,003–42,761,468 | 16.0 kb | Distal (>10kb) Multiome | 335 | |
| chr17:42,780,029–42,780,899 | 35.5 kb | Distal (>10kb) Multiome | 712 | |
| chr17:42,798,408–42,798,877 | 53.7 kb | Distal (>10kb) Multiome | 866 | |
| chr17:42,823,968–42,824,503 | 79.3 kb | Distal (>10kb) Multiome | 829 | |
| chr17:42,832,889–42,833,841 | 88.3 kb | Distal (>10kb) Multiome | 980 | |
| chr17:42,964,237–42,964,843 | 219.5 kb | Distal (>10kb) Multiome | 655 | |
| chr17:42,979,966–42,981,044 | 235.4 kb | Distal (>10kb) Multiome | 843 | |
| chr17:42,997,598–42,998,917 | 253.3 kb | Distal (>10kb) Multiome | 1112 | |
| chr17:43,021,026–43,022,568 | 277.3 kb | Distal (>10kb) Multiome | 973 | |
| chr17:43,024,255–43,025,752 | 280.0 kb | Distal (>10kb) Multiome | 811 |
Genomic view of the EZH1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.