This gene encodes a nuclear protein, which contains a homeobox domain and is a transcription factor. Mutations in this gene result in Currarino syndrome, an autosomic dominant congenital malformation. Alternatively spliced transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Sep 2009]
Transcription factors with Perturb-seq knockdown data for MNX1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = MNX1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of MNX1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr7:155,466,156–155,467,479 | 1543.8 kb | Distal (>10kb) Multiome HiCAR | 270 | |
| chr7:155,467,594–155,468,737 | 1542.5 kb | Distal (>10kb) Multiome HiCAR | 231 | |
| chr7:155,802,850–155,806,571 | 1206.9 kb | Distal (>10kb) Multiome HiCAR | 556 | |
| chr7:156,892,088–156,893,883 | 117.3 kb | Distal (>10kb) Multiome | 1026 | |
| chr7:156,948,934–156,950,397 | 61.0 kb | Distal (>10kb) Multiome | 895 | |
| chr7:156,999,533–157,000,740 | 9.9 kb | Proximal (<10kb) | 433 | |
| chr7:157,003,166–157,003,532 | 7.1 kb | Proximal (<10kb) | 120 | |
| chr7:157,003,648–157,004,372 | 6.6 kb | Proximal (<10kb) Multiome | 255 | |
| chr7:157,009,113–157,012,019 | 115 bp | At TSS Multiome | 793 | |
| chr7:157,013,630–157,014,425 | 3.4 kb | Proximal (<10kb) Multiome | 180 | |
| chr7:157,017,564–157,018,575 | 6.9 kb | Proximal (<10kb) | 123 | |
| chr7:157,018,926–157,019,665 | 8.3 kb | Proximal (<10kb) | 143 | |
| chr7:157,138,376–157,139,695 | 128.1 kb | Distal (>10kb) Multiome HiCAR | 863 |
Genomic view of the MNX1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.