Enables mRNA binding activity. Involved in regulation of alternative mRNA splicing, via spliceosome and regulation of apoptotic process. Located in nuclear speck. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for RBM25. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = RBM25 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of RBM25, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr14:72,893,140–72,894,397 | 164.3 kb | Distal (>10kb) Multiome | 484 | |
| chr14:72,925,756–72,927,231 | 132.2 kb | Distal (>10kb) Multiome | 799 | |
| chr14:73,026,575–73,027,593 | 31.4 kb | Distal (>10kb) Multiome | 727 | |
| chr14:73,058,025–73,059,316 | 51 bp | At TSS Multiome | 949 | |
| chr14:73,125,023–73,126,032 | 66.9 kb | Distal (>10kb) Multiome | 131 | |
| chr14:73,136,098–73,137,113 | 77.9 kb | Distal (>10kb) Multiome | 737 | |
| chr14:73,168,802–73,169,764 | 110.7 kb | Distal (>10kb) Multiome | 44 | |
| chr14:73,235,444–73,236,071 | 177.2 kb | Distal (>10kb) Multiome | 85 | |
| chr14:73,237,315–73,238,355 | 179.3 kb | Distal (>10kb) Multiome | 296 |
Genomic view of the RBM25 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.