The protein encoded by this gene belongs to the Kruppel family of C2H2-type zinc finger proteins. It contains 31 C2H2-type zinc fingers and may be involved in transcriptional regulation. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Jan 2013]
Transcription factors with Perturb-seq knockdown data for ZNF142. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ZNF142 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ZNF142, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr2:218,367,421–218,368,194 | 291.7 kb | Distal (>10kb) Multiome | 450 | |
| chr2:218,387,091–218,388,220 | 271.6 kb | Distal (>10kb) Multiome | 514 | |
| chr2:218,395,568–218,397,399 | 263.3 kb | Distal (>10kb) Multiome | 1048 | |
| chr2:218,397,484–218,401,433 | 261.6 kb | Distal (>10kb) Multiome | 1114 | |
| chr2:218,405,424–218,407,478 | 253.1 kb | Distal (>10kb) Multiome | 1093 | |
| chr2:218,567,787–218,569,400 | 91.0 kb | Distal (>10kb) Multiome | 1083 | |
| chr2:218,658,668–218,660,011 | 72 bp | At TSS Multiome | 870 | |
| chr2:218,671,689–218,672,558 | 12.5 kb | Distal (>10kb) Multiome | 794 | |
| chr2:218,710,272–218,711,420 | 51.3 kb | Distal (>10kb) Multiome | 957 | |
| chr2:218,781,682–218,782,718 | 122.6 kb | Distal (>10kb) Multiome | 674 | |
| chr2:218,798,810–218,799,640 | 139.7 kb | Distal (>10kb) Multiome | 163 | |
| chr2:218,799,866–218,800,388 | 140.8 kb | Distal (>10kb) Multiome | 82 | |
| chr2:218,860,491–218,861,382 | 201.5 kb | Distal (>10kb) Multiome | 241 | |
| chr2:218,883,560–218,884,239 | 224.4 kb | Distal (>10kb) Multiome | 190 | |
| chr2:218,892,714–218,893,400 | 233.4 kb | Distal (>10kb) Multiome | 591 | |
| chr2:218,898,077–218,898,730 | 238.9 kb | Distal (>10kb) Multiome | 624 | |
| chr2:218,908,757–218,909,543 | 249.6 kb | Distal (>10kb) Multiome | 885 | |
| chr2:218,959,145–218,960,352 | 300.0 kb | Distal (>10kb) Multiome | 416 |
Genomic view of the ZNF142 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.