The DNA-associated protein encoded by this gene is a member of the paired family of homeobox proteins. Expression is localized to proliferating fetal fibroblasts and the developing dermal layer, with downregulated expression in adult skin. Increases in expression of this gene during fetal but not adult wound healing suggest a possible role in mechanisms that control mammalian dermal regeneration and prevent formation of scar response to wounding. The expression patterns provide evidence consistent with a role in fetal skin development and a possible role in cellular proliferation. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for PRRX2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = PRRX2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of PRRX2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr9:129,413,561–129,414,426 | 251.8 kb | Distal (>10kb) Multiome | 753 | |
| chr9:129,495,758–129,497,403 | 168.7 kb | Distal (>10kb) Multiome | 973 | |
| chr9:129,557,196–129,557,935 | 108.1 kb | Distal (>10kb) Multiome | 718 | |
| chr9:129,626,055–129,626,580 | 39.4 kb | Distal (>10kb) Multiome | 825 | |
| chr9:129,641,895–129,642,673 | 23.3 kb | Distal (>10kb) Multiome | 919 | |
| chr9:129,802,988–129,803,555 | 137.5 kb | Distal (>10kb) Multiome | 727 | |
| chr9:129,835,192–129,835,687 | 169.8 kb | Distal (>10kb) Multiome | 701 |
Genomic view of the PRRX2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.