Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of DNA-templated transcription. Predicted to be located in nucleus. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for ZNF92. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ZNF92 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ZNF92, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr7:65,080,759–65,081,624 | 292.6 kb | Distal (>10kb) Multiome | 273 | |
| chr7:65,233,376–65,233,924 | 140.1 kb | Distal (>10kb) Multiome | 61 | |
| chr7:65,239,449–65,240,350 | 133.9 kb | Distal (>10kb) Multiome | 420 | |
| chr7:65,251,663–65,252,869 | 121.5 kb | Distal (>10kb) Multiome | 690 | |
| chr7:65,268,929–65,270,162 | 104.5 kb | Distal (>10kb) Multiome | 581 | |
| chr7:65,373,299–65,374,394 | 30 bp | At TSS Multiome | 738 |
Genomic view of the ZNF92 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.