This gene encodes a member of the TET family of RNA-binding proteins. The encoded protein plays a role in RNA polymerase II gene transcription as a component of a distinct subset of multi-subunit transcription initiation factor TFIID complexes. Translocations involving this gene play a role in acute leukemia and extraskeletal myxoid chondrosarcoma, and mutations in this gene may play a role in amyotrophic lateral sclerosis. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, May 2012]
Transcription factors with Perturb-seq knockdown data for TAF15. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = TAF15 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of TAF15, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr17:35,567,580–35,568,368 | 241.5 kb | Distal (>10kb) Multiome | 673 | |
| chr17:35,578,257–35,578,977 | 230.8 kb | Distal (>10kb) Multiome | 860 | |
| chr17:35,586,924–35,588,023 | 222.1 kb | Distal (>10kb) Multiome | 932 | |
| chr17:35,731,320–35,732,101 | 77.8 kb | Distal (>10kb) Multiome | 406 | |
| chr17:35,763,993–35,764,924 | 45.1 kb | Distal (>10kb) Multiome | 888 | |
| chr17:35,795,171–35,795,832 | 14.0 kb | Distal (>10kb) Multiome | 290 | |
| chr17:35,804,814–35,805,061 | 4.4 kb | Proximal (<10kb) | 297 | |
| chr17:35,808,939–35,810,190 | 107 bp | At TSS Multiome | 899 | |
| chr17:35,849,572–35,849,755 | 4.6 kb | Proximal (<10kb) | 118 | |
| chr17:35,930,498–35,930,976 | 121.3 kb | Distal (>10kb) Multiome | 353 | |
| chr17:35,942,380–35,943,327 | 133.4 kb | Distal (>10kb) Multiome | 169 |
Genomic view of the TAF15 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.