This gene encodes a member of the even-skipped homeobox family characterized by the presence of a homeodomain closely related to the Drosophila even-skipped (eve) segmentation gene of the pair-rule class. The encoded protein may play an important role as a transcriptional repressor during embryogenesis. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for EVX1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = EVX1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of EVX1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr7:27,235,136–27,236,870 | 5.9 kb | Proximal (<10kb) | 402 | |
| chr7:27,237,597–27,238,265 | 4.5 kb | Proximal (<10kb) | 48 | |
| chr7:27,239,185–27,240,005 | 2.8 kb | Proximal (<10kb) | 169 | |
| chr7:27,240,139–27,240,815 | 2.0 kb | Proximal (<10kb) | 47 | |
| chr7:27,241,175–27,241,484 | 1.3 kb | Proximal (<10kb) | 23 | |
| chr7:27,242,123–27,244,895 | at TSS | At TSS | 389 | |
| chr7:27,245,482–27,246,574 | 2.7 kb | Proximal (<10kb) | 136 | |
| chr7:27,251,495–27,252,545 | 8.7 kb | Proximal (<10kb) | 109 |
Genomic view of the EVX1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.