This gene encodes a member of the POU protein family characterized by the presence of a bipartite DNA binding domain, consisting of a POU-specific domain and a homeodomain, separated by a variable polylinker. The DNA binding domain may bind to DNA as monomers or as homo- and/or heterodimers, in a sequence-specific manner. The POU family members are transcriptional regulators, many of which are known to control cell type-specific differentiation pathways. This gene is a tumor suppressor involved in Wilms tumor (WT) predisposition. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene.[provided by RefSeq, Oct 2009]
Transcription factors with Perturb-seq knockdown data for POU6F2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = POU6F2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of POU6F2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr7:38,908,653–38,909,350 | 104.0 kb | Distal (>10kb) Multiome HiCAR | 567 | |
| chr7:39,085,412–39,086,069 | at TSS | At TSS | 181 | |
| chr7:39,088,851–39,089,008 | 3.0 kb | Proximal (<10kb) | 24 | |
| chr7:39,250,012–39,250,755 | 237.4 kb | Distal (>10kb) Multiome | 102 | |
| chr7:39,353,499–39,355,182 | 340.8 kb | Distal (>10kb) Multiome | 344 | |
| chr7:39,413,990–39,414,973 | 401.5 kb | Distal (>10kb) Multiome | 460 | |
| chr7:39,566,027–39,566,876 | 553.3 kb | Distal (>10kb) Multiome | 879 | |
| chr7:39,622,891–39,624,257 | 610.4 kb | Distal (>10kb) Multiome | 867 | |
| chr7:39,732,821–39,734,237 | 720.3 kb | Distal (>10kb) Multiome | 702 |
Genomic view of the POU6F2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.