The protein encoded by this gene acts as a transcriptional coactivator for steroid and nuclear hormone receptors. It is a member of the p160/steroid receptor coactivator (SRC) family and like other family members has histone acetyltransferase activity and contains a nuclear localization signal, as well as bHLH and PAS domains. The product of this gene binds nuclear receptors directly and stimulates the transcriptional activities in a hormone-dependent fashion. Alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for NCOA1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = NCOA1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of NCOA1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr2:24,191,824–24,192,305 | 299.3 kb | Distal (>10kb) Multiome | 68 | |
| chr2:24,280,210–24,280,709 | 210.9 kb | Distal (>10kb) Multiome | 38 | |
| chr2:24,315,559–24,316,125 | 175.5 kb | Distal (>10kb) Multiome | 99 | |
| chr2:24,359,764–24,361,015 | 130.7 kb | Distal (>10kb) Multiome | 909 | |
| chr2:24,456,964–24,457,548 | 34.0 kb | Distal (>10kb) Multiome | 112 | |
| chr2:24,489,608–24,492,569 | 248 bp | At TSS Multiome | 854 | |
| chr2:24,792,642–24,794,076 | 302.0 kb | Distal (>10kb) Multiome HiCAR | 1010 |
Genomic view of the NCOA1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.