This gene encodes a homeobox transcription factor that is involved in somitogenesis and neurogenesis and is required for the maintenance and differentiation of specific elements of the axial skeleton. This gene also plays a role in controlling the development of connections of hypothalamic neurons to pituitary elements, allowing central neurons to reach the peripheral blood circulation and deliver hormones that control peripheral functions. The expression of this gene is associated with an increased frequency of acute myeloid leukemia. [provided by RefSeq, Jul 2017]
Transcription factors with Perturb-seq knockdown data for UNCX. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = UNCX upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of UNCX, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr7:1,225,592–1,225,755 | 7.1 kb | Proximal (<10kb) | 232 | |
| chr7:1,229,514–1,230,231 | 2.6 kb | Proximal (<10kb) | 97 | |
| chr7:1,231,102–1,231,732 | 1.1 kb | Proximal (<10kb) | 84 | |
| chr7:1,235,892–1,237,020 | 3.0 kb | Proximal (<10kb) | 184 | |
| chr7:1,242,250–1,242,956 | 9.4 kb | Proximal (<10kb) | 95 |
Genomic view of the UNCX locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.