MXI1

MAX interactor 1, dimerization protein | MAD2, MXD2, MXI, bHLHc11

Expression of the c-myc gene, which produces an oncogenic transcription factor, is tightly regulated in normal cells but is frequently deregulated in human cancers. The protein encoded by this gene is a transcriptional repressor thought to negatively regulate MYC function, and is therefore a potential tumor suppressor. This protein inhibits the transcriptional activity of MYC by competing for MAX, another basic helix-loop-helix protein that binds to MYC and is required for its function. Defects in this gene are frequently found in patients with prostate tumors. Three alternatively spliced transcripts encoding different isoforms have been described. Additional alternatively spliced transcripts may exist but the products of these transcripts have not been verified experimentally. [provided by RefSeq, Jul 2008]

Member of: DE-3 DE-3.39 Developmental clusters: GC6

Biological processes 15 terms

DNA-binding transcription factor activity, RNA polymerase II-specific (GO:0000981)DNA-binding transcription factor activity, RNA polymerase II-specific (GO:0000981)DNA-binding transcription repressor activity, RNA polymerase II-specific (GO:0001227)RNA polymerase II cis-regulatory region sequence-specific DNA binding (GO:0000978)RNA polymerase II transcription regulator complex (GO:0090575)RNA polymerase II transcription regulatory region sequence-specific DNA binding (GO:0000977)chromatin (GO:0000785)negative regulation of transcription by RNA polymerase II (GO:0000122)nucleoplasm (GO:0005654)nucleus (GO:0005634)nucleus (GO:0005634)nucleus (GO:0005634)protein binding (GO:0005515)protein dimerization activity (GO:0046983)regulation of transcription by RNA polymerase II (GO:0006357)

Expression (TPM)

TFs regulating MXI1 0 TFs

Transcription factors with Perturb-seq knockdown data for MXI1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = MXI1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.

TF	Mean coef	Binding	Outlier	TF→Gene link

Rows:

Elements linked to MXI1

Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of MXI1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.

Element	Dist. to TSS	Link type	TFs
chr10:109,883,984–109,884,981	323.2 kb	Distal (>10kb) Multiome HiCAR	460
chr10:109,922,853–109,924,531	284.1 kb	Distal (>10kb) Multiome	670
chr10:109,934,169–109,935,521	272.5 kb	Distal (>10kb) Multiome	274
chr10:109,996,780–109,997,611	210.3 kb	Distal (>10kb) Multiome	150
chr10:110,006,797–110,009,028	199.7 kb	Distal (>10kb) Multiome	867
chr10:110,081,755–110,082,396	125.5 kb	Distal (>10kb) Multiome	288
chr10:110,168,513–110,169,827	38.4 kb	Distal (>10kb) Multiome HiCAR	325
chr10:110,181,115–110,182,697	25.9 kb	Distal (>10kb) Multiome	325
chr10:110,205,984–110,208,438	16 bp	At TSS Multiome	727
chr10:110,209,115–110,211,789	2.3 kb	Proximal (<10kb) Multiome	928
chr10:110,221,648–110,222,161	3.8 kb	Proximal (<10kb)	438
chr10:110,225,399–110,227,748	19.2 kb	Distal (>10kb) Multiome	766
chr10:110,304,286–110,305,616	97.4 kb	Distal (>10kb) Multiome	717
chr10:110,324,327–110,325,094	117.1 kb	Distal (>10kb) Multiome	220
chr10:110,483,548–110,484,272	276.2 kb	Distal (>10kb) Multiome	273
chr10:110,493,733–110,494,428	286.5 kb	Distal (>10kb) Multiome	112
chr10:110,497,303–110,499,967	290.2 kb	Distal (>10kb) Multiome	772

Genome Browser

Genomic view of the MXI1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.