Enables DNA-binding transcription factor activity, RNA polymerase II-specific and sequence-specific double-stranded DNA binding activity. Predicted to be involved in generation of neurons; olfactory bulb development; and regulation of transcription by RNA polymerase II. Predicted to act upstream of or within several processes, including nervous system development; positive regulation of Notch signaling pathway; and positive regulation of oligodendrocyte differentiation. Located in cytoplasm and nucleus. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for GSX2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = GSX2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of GSX2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr4:54,091,094–54,091,615 | 8.5 kb | Proximal (<10kb) | 273 | |
| chr4:54,091,806–54,092,443 | 7.7 kb | Proximal (<10kb) | 448 | |
| chr4:54,093,443–54,094,337 | 5.8 kb | Proximal (<10kb) | 51 | |
| chr4:54,095,224–54,095,775 | 4.4 kb | Proximal (<10kb) | 28 | |
| chr4:54,099,424–54,101,068 | at TSS | At TSS | 200 | |
| chr4:54,101,515–54,101,678 | 1.4 kb | Proximal (<10kb) | 36 | |
| chr4:54,103,204–54,104,370 | 3.0 kb | Proximal (<10kb) | 120 | |
| chr4:54,109,645–54,109,962 | 9.5 kb | Proximal (<10kb) | 88 |
Genomic view of the GSX2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.