Enables DNA-binding transcription repressor activity, RNA polymerase II-specific and sequence-specific double-stranded DNA binding activity. Involved in negative regulation of transcription by RNA polymerase II. Located in actin cytoskeleton and nuclear body. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for POU6F1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = POU6F1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of POU6F1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr12:51,025,646–51,026,823 | 191.7 kb | Distal (>10kb) Multiome | 1016 | |
| chr12:51,047,625–51,048,573 | 169.9 kb | Distal (>10kb) Multiome | 892 | |
| chr12:51,082,637–51,083,972 | 134.5 kb | Distal (>10kb) Multiome | 937 | |
| chr12:51,172,263–51,173,510 | 45.0 kb | Distal (>10kb) Multiome HiCAR | 853 | |
| chr12:51,217,044–51,218,599 | 20 bp | At TSS Multiome | 687 | |
| chr12:51,238,201–51,239,451 | 20.9 kb | Distal (>10kb) Multiome | 891 | |
| chr12:51,269,409–51,270,816 | 51.9 kb | Distal (>10kb) Multiome | 750 | |
| chr12:51,320,220–51,321,248 | 102.8 kb | Distal (>10kb) Multiome | 315 | |
| chr12:51,371,336–51,371,863 | 153.6 kb | Distal (>10kb) Multiome | 431 | |
| chr12:51,390,937–51,392,088 | 173.5 kb | Distal (>10kb) Multiome | 504 | |
| chr12:51,395,449–51,396,000 | 177.7 kb | Distal (>10kb) Multiome | 274 | |
| chr12:51,424,595–51,425,524 | 206.9 kb | Distal (>10kb) Multiome | 499 |
Genomic view of the POU6F1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.