This gene encodes a transcriptional regulator that belongs to the BET (bromodomains and extra terminal domain) family of proteins. This protein associates with transcription complexes and with acetylated chromatin during mitosis, and it selectively binds to the acetylated lysine-12 residue of histone H4 via its two bromodomains. The gene maps to the major histocompatability complex (MHC) class II region on chromosome 6p21.3, but sequence comparison suggests that the protein is not involved in the immune response. This gene has been implicated in juvenile myoclonic epilepsy, a common form of epilepsy that becomes apparent in adolescence. Multiple alternatively spliced variants have been described for this gene. [provided by RefSeq, Dec 2010]
Transcription factors with Perturb-seq knockdown data for BRD2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = BRD2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of BRD2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr6:32,837,981–32,838,977 | 130.0 kb | Distal (>10kb) Multiome | 821 | |
| chr6:32,844,222–32,845,071 | 123.9 kb | Distal (>10kb) Multiome | 534 | |
| chr6:32,853,077–32,854,448 | 114.5 kb | Distal (>10kb) Multiome | 841 | |
| chr6:32,893,822–32,895,230 | 74.0 kb | Distal (>10kb) Multiome | 774 | |
| chr6:32,952,883–32,953,496 | 15.4 kb | Distal (>10kb) Multiome | 366 | |
| chr6:32,967,391–32,967,842 | 750 bp | At TSS | 409 | |
| chr6:32,967,972–32,971,214 | 162 bp | At TSS Multiome | 1227 | |
| chr6:32,971,467–32,973,408 | 3.4 kb | Proximal (<10kb) Multiome | 1115 | |
| chr6:32,973,916–32,974,189 | 5.3 kb | Proximal (<10kb) | 88 | |
| chr6:33,009,348–33,009,899 | 41.1 kb | Distal (>10kb) Multiome | 184 | |
| chr6:33,080,635–33,081,087 | 112.1 kb | Distal (>10kb) Multiome | 141 | |
| chr6:33,161,505–33,162,100 | 193.1 kb | Distal (>10kb) Multiome | 589 | |
| chr6:33,199,801–33,201,289 | 232.1 kb | Distal (>10kb) Multiome | 1049 | |
| chr6:33,204,263–33,205,422 | 236.0 kb | Distal (>10kb) Multiome | 762 | |
| chr6:33,208,069–33,208,990 | 240.0 kb | Distal (>10kb) Multiome | 858 | |
| chr6:33,248,132–33,249,983 | 279.7 kb | Distal (>10kb) Multiome | 961 |
Genomic view of the BRD2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.