The protein encoded by this gene contains multiple tandem zinc finger motifs. The encoded protein is involved in the differentiation of erythroid and megakaryocytic cells. This gene is located in a cluster of related genes on chromosome 8 encoding zinc finger proteins. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Sep 2012]
Transcription factors with Perturb-seq knockdown data for ZNF16. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ZNF16 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ZNF16, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr8:144,672,507–144,672,989 | 278.0 kb | Distal (>10kb) Multiome | 150 | |
| chr8:144,684,108–144,686,340 | 266.5 kb | Distal (>10kb) Multiome | 862 | |
| chr8:144,755,078–144,755,956 | 195.3 kb | Distal (>10kb) Multiome | 769 | |
| chr8:144,785,987–144,788,592 | 163.7 kb | Distal (>10kb) Multiome | 997 | |
| chr8:144,791,751–144,793,221 | 158.4 kb | Distal (>10kb) Multiome | 899 | |
| chr8:144,798,389–144,799,501 | 152.0 kb | Distal (>10kb) Multiome | 832 | |
| chr8:144,826,059–144,827,981 | 123.5 kb | Distal (>10kb) Multiome | 905 | |
| chr8:144,852,614–144,853,614 | 97.7 kb | Distal (>10kb) Multiome | 850 | |
| chr8:144,900,754–144,902,675 | 49.3 kb | Distal (>10kb) Multiome | 1021 | |
| chr8:144,950,374–144,951,024 | 115 bp | At TSS Multiome | 695 | |
| chr8:145,002,551–145,003,548 | 52.1 kb | Distal (>10kb) Multiome | 872 | |
| chr8:145,051,576–145,052,751 | 101.5 kb | Distal (>10kb) Multiome | 797 |
Genomic view of the ZNF16 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.