chr16:8,588,655–8,589,263

chr16 : 8,588,655 – 8,589,263

608 bp 96 TFs 6 linked genes

This 608 bp open chromatin element is linked to 6 target genes and is bound by 96 transcription factors.

Linked Genes

6 genes

Gene	Expression	Dist. to TSS	Distance	Link type
TMEM114		1.2 kb	Proximal	Proximity
METTL22		32.8 kb	Distal	Multiome
ABAT		85.8 kb	Distal	Multiome
TMEM186		208.8 kb	Distal	Multiome
PMM2		209.0 kb	Distal	Multiome
CARHSP1		279.9 kb	Distal	Multiome

Chromatin Accessibility

Genome Browser

Genomic view centred on this element. Tracks include ATAC-seq accessibility, RNA-seq expression, TF binding peaks, and element-to-gene loop arcs across the ESC → DE time course.

Transcription factors with ChIP-seq peak overlap or TOBIAS motif footprint evidence at this element.

TF Binding

96 transcription factors

AGO1 2 datasets

ChIP Hep-G2 ENCSR555ZMV.AGO1.Hep-G2 148 bp overlap

ChIP Hep-G2 GSE120104.AGO1.Hep-G2 95 bp overlap

ChIP breast_tumor_Male_20 GSE104399.AR.breast_tumor_Male_20 203 bp overlap

ARID4B 1 dataset

ChIP WTC11 ENCFF441HDK 457 bp overlap

ASH2L 1 dataset

ChIP H1 ENCFF399KAM 608 bp overlap

ChIP WA01 ENCSR000BQU.ATF2.WA01 155 bp overlap

ChIP WA01_KDM2B_KO GSE104690.BCOR.WA01_KDM2B_KO 361 bp overlap

ChIP HUES-64 GSE104059.BRD1.HUES-64 538 bp overlap

ChIP MV4-11_IBET151_500nM GSE120715.BRD2.MV4-11_IBET151_500nM 245 bp overlap

BRD4 7 datasets

ChIP CLL_patient2 GSE109411.BRD4.CLL_patient2 147 bp overlap

ChIP CLL_patient3_4h_CpG GSE109411.BRD4.CLL_patient3_4h_CpG 157 bp overlap

ChIP CLL_patient3_4h_CpG_BET GSE109411.BRD4.CLL_patient3_4h_CpG_BET 120 bp overlap

ChIP CLL_patient4_4h_CpG_BET GSE109411.BRD4.CLL_patient4_4h_CpG_BET 216 bp overlap

ChIP MCF-10A ERP003925.BRD4.MCF-10A 182 bp overlap

ChIP MV4-11_IBET151_50nM GSE120715.BRD4.MV4-11_IBET151_50nM 160 bp overlap

ChIP retina_AB1-FW15 GSE86981.BRD4.retina_AB1-FW15 440 bp overlap

CEBPB 2 datasets

ChIP H1 ENCFF871PTR 261 bp overlap

ChIP WA01 ENCSR000EBV.CEBPB.WA01 135 bp overlap

ChIP WA01 ENCSR000AQK.CHD1.WA01 342 bp overlap

ChIP WA01 ENCSR000AVA.CHD7.WA01 75 bp overlap

CTBP2 1 dataset

ChIP WA01 ENCSR000EUO.CTBP2.WA01 426 bp overlap

ChIP brain ENCFF685VRG 90 bp overlap

ChIP WTC11 ENCFF449LLF 335 bp overlap

ChIP WA01 ENCSR000BSI.E2F6.WA01 118 bp overlap

ChIP ProEs GSE59087.EED.ProEs 411 bp overlap

ChIP A-375 GSE116190.EGR1.A-375 173 bp overlap

ESR1 3 datasets

ChIP Ishikawa_siETV4-72h GSE129803.ESR1.Ishikawa_siETV4-72h 151 bp overlap

ChIP MCF-7_PaPE-1_OA GSE93510.ESR1.MCF-7_PaPE-1_OA 389 bp overlap

ChIP T-47D_Y537S_E2 GSE148277.ESR1.T-47D_Y537S_E2 313 bp overlap

EZH2 32 datasets

ChIP A-1847_CARM1-KO GSE95643.EZH2.A-1847_CARM1-KO 408 bp overlap

ChIP B-cell ENCSR000AUZ.EZH2.B-cell 526 bp overlap

ChIP GM23248 ENCFF404ZHM 481 bp overlap

ChIP GM23248 ENCFF404ZHM 278 bp overlap

ChIP GM23338 ENCFF613YON 76 bp overlap

ChIP H1 ENCFF232NZA 160 bp overlap

ChIP HUVEC-C GSE109625.EZH2.HUVEC-C 227 bp overlap

ChIP LNCaP GSE39459.EZH2.LNCaP 195 bp overlap

ChIP PC-9 ENCSR793USK.EZH2.PC-9 306 bp overlap

ChIP ProEs GSE59087.EZH2.ProEs 224 bp overlap

ChIP ProEs_SHCTR GSE59087.EZH2.ProEs_SHCTR 102 bp overlap

ChIP SF8628 GSE94834.EZH2.SF8628 608 bp overlap

ChIP VCaP_DHAT_2H GSE28950.EZH2.VCaP_DHAT_2H 158 bp overlap

ChIP VCaP_DHAT_2H GSE28950.EZH2.VCaP_DHAT_2H 124 bp overlap

ChIP VCaP_ETOH GSE28950.EZH2.VCaP_ETOH 310 bp overlap

ChIP astrocyte ENCFF365JTP 201 bp overlap

ChIP dermal-fibroblast_Preneoplastic GSE126396.EZH2.dermal-fibroblast_Preneoplastic 608 bp overlap

ChIP dermal-fibroblast_Transformed GSE126396.EZH2.dermal-fibroblast_Transformed 399 bp overlap

ChIP dermal-fibroblast_Untransformed GSE126396.EZH2.dermal-fibroblast_Untransformed 173 bp overlap

ChIP dermal-fibroblast_Untransformed GSE126396.EZH2.dermal-fibroblast_Untransformed 145 bp overlap

ChIP endothelial cell of umbilical vein ENCFF539AKL 300 bp overlap

ChIP endothelial cell of umbilical vein ENCFF539AKL 95 bp overlap

ChIP fibroblast of lung ENCFF479BAW 214 bp overlap

ChIP hepatocyte ENCFF552DZB 82 bp overlap

ChIP keratinocyte ENCFF070STK 52 bp overlap

ChIP myoblast_skeletal_muscle ENCSR000ARH.EZH2.myoblast_skeletal_muscle 65 bp overlap

ChIP neural ENCSR511CUH.EZH2.neural 67 bp overlap

ChIP neural progenitor cell ENCFF472NFV 608 bp overlap

ChIP neural progenitor cell ENCFF472NFV 335 bp overlap

ChIP prostate-cancer_HA GSE107780.EZH2.prostate-cancer_HA 78 bp overlap

ChIP skeletal muscle myoblast ENCFF338LNF 373 bp overlap

ChIP skeletal muscle myoblast ENCFF338LNF 145 bp overlap

EZH2_phosphoT487 2 datasets

ChIP GM23248 ENCSR096KPA.EZH2_phosphoT487.GM23248 263 bp overlap

ChIP GM23248 ENCSR096KPA.EZH2_phosphoT487.GM23248 224 bp overlap

FOXA1 1 dataset

ChIP breast-cancer_heregulin-Herceptin-ICI GSE101407.FOXA1.breast-cancer_heregulin-Herceptin-ICI 51 bp overlap

GABPA 1 dataset

ChIP WA01 ENCSR000BIW.GABPA.WA01 180 bp overlap

GATA3 1 dataset

ChIP breast_tumor_Male_15 GSE104399.GATA3.breast_tumor_Male_15 233 bp overlap

GATA6 1 dataset

ChIP HUES-8_DE_JNKi GSE109524.GATA6.HUES-8_DE_JNKi 255 bp overlap

GLIS3 1 dataset

ChIP H9_plus GSE109562.GLIS3.H9_plus 468 bp overlap

GTF3C2 1 dataset

ChIP H9 GSE94418.GTF3C2.H9 396 bp overlap

HDAC2 3 datasets

ChIP H1 ENCFF939VKA 237 bp overlap

ChIP WA01 ENCSR000AVB.HDAC2.WA01 608 bp overlap

ChIP WA01 ENCSR000BNR.HDAC2.WA01 204 bp overlap

HIF3A 1 dataset

ChIP Hep-3B2-1-7 GSE129491.HIF3A.Hep-3B2-1-7 137 bp overlap

HIVEP1 2 datasets

ChIP Hep-G2 ENCSR697WMX.HIVEP1.Hep-G2 195 bp overlap

ChIP HepG2 ENCFF063BCC 280 bp overlap

HNRNPH1 1 dataset

ChIP Hep-G2 ENCSR066FXN.HNRNPH1.Hep-G2 233 bp overlap

HNRNPLL 2 datasets

ChIP Hep-G2 ENCSR804HMZ.HNRNPLL.Hep-G2 177 bp overlap

ChIP Hep-G2 GSE120104.HNRNPLL.Hep-G2 160 bp overlap

JARID2 2 datasets

ChIP EDOMIPS2 GSE48516.JARID2.EDOMIPS2 165 bp overlap

ChIP UTEIPS11 GSE48516.JARID2.UTEIPS11 313 bp overlap

ChIP DE_D2 S02-DE-d2-JUN-exp1 378 bp overlap

ChIP HUES-8 GSE109524.JUN.HUES-8 429 bp overlap

JUND 2 datasets

ChIP H1 ENCFF468JZD 231 bp overlap

ChIP WA01 ENCSR000BKP.JUND.WA01 138 bp overlap

KDM4A 1 dataset

ChIP WA01 ENCSR000AVC.KDM4A.WA01 182 bp overlap

ChIP MCF-7_SHRARS_E2 GSE60270.MED1.MCF-7_SHRARS_E2 133 bp overlap

MNX1 2 datasets

ChIP Hep-G2 ENCSR108MKR.MNX1.Hep-G2 59 bp overlap

ChIP HepG2 ENCFF938KYA 193 bp overlap

MXD1 2 datasets

ChIP HepG2 ENCFF717MYN 282 bp overlap

ChIP HepG2 ENCFF717MYN 73 bp overlap

ChIP neural ENCSR934NHU.MXI1.neural 263 bp overlap

MYBL2 1 dataset

ChIP A-673 GSE119971.MYBL2.A-673 608 bp overlap

NANOG 5 datasets

ChIP HUES-8 GSE109524.NANOG.HUES-8 608 bp overlap

ChIP WA01_3IL ERP004238.NANOG.WA01_3IL 341 bp overlap

ChIP WA09 GSE105028.NANOG.WA09 249 bp overlap

ChIP WA09_heat-shock GSE105028.NANOG.WA09_heat-shock 297 bp overlap

ChIP hESC GSE18292.NANOG.hESC 358 bp overlap

NFKB1 2 datasets

ChIP HEK293T GSE129618.NFKB1.HEK293T 218 bp overlap

ChIP HEK293T_2KR GSE129618.NFKB1.HEK293T_2KR 263 bp overlap

PCBP1 1 dataset

ChIP Hep-G2 GSE120104.PCBP1.Hep-G2 161 bp overlap

PDX1 2 datasets

ChIP hiPSC GSE125768.PDX1.hiPSC 301 bp overlap

ChIP hiPSC_derived_PPs GSE106949.PDX1.hiPSC_derived_PPs 211 bp overlap

PITX1 1 dataset

ChIP HepG2 ENCFF468QTQ 59 bp overlap

POLR2A 2 datasets

ChIP GM23338 ENCFF450WCS 356 bp overlap

ChIP GM23338 ENCFF450WCS 491 bp overlap

POU2F1 1 dataset

ChIP HepG2 ENCFF422JZU 189 bp overlap

POU5F1 8 datasets

ChIP BG03 GSE21614.POU5F1.BG03 122 bp overlap

ChIP DE_D1 DED1-OCT4_Batch_II 477 bp overlap

ChIP HUES-8 GSE109524.POU5F1.HUES-8 608 bp overlap

ChIP WA09 GSE105028.POU5F1.WA09 175 bp overlap

ChIP WA09_heat-shock GSE105028.POU5F1.WA09_heat-shock 188 bp overlap

ChIP hESC ENCSR264RJX.POU5F1.hESC 113 bp overlap

ChIP hESC_PRIMED GSE69646.POU5F1.hESC_PRIMED 451 bp overlap

ChIP hiPSC GSE56567.POU5F1.hiPSC 221 bp overlap

POU5F1_M 1 dataset

ChIP DE_D1 DED1-OCT4-M_Batch_II 579 bp overlap

PRDM15 1 dataset

ChIP WTC11 ENCFF108TMF 401 bp overlap

ChIP HepG2 ENCFF763DFQ 173 bp overlap

PTBP1 1 dataset

ChIP Hep-G2 ENCSR156APP.PTBP1.Hep-G2 158 bp overlap

RARA 2 datasets

ChIP hiPSC_D3 GSE109172.RARA.hiPSC_D3 262 bp overlap

ChIP hiPSC_D4 GSE109172.RARA.hiPSC_D4 230 bp overlap

RBBP5 2 datasets

ChIP H1 ENCFF905HFL 165 bp overlap

ChIP WA01 ENCSR000AQC.RBBP5.WA01 519 bp overlap

RBM39 6 datasets

ChIP Hep-G2 ENCSR339JTP.RBM39.Hep-G2 110 bp overlap

ChIP Hep-G2 GSE120104.RBM39.Hep-G2 108 bp overlap

ChIP HepG2 ENCFF084YZE 327 bp overlap

ChIP HepG2 ENCFF084YZE 126 bp overlap

ChIP HepG2 ENCFF801JUH 325 bp overlap

ChIP HepG2 ENCFF801JUH 124 bp overlap

RBPJ 2 datasets

ChIP HepG2 ENCFF367CFI 409 bp overlap

ChIP HepG2 ENCFF367CFI 158 bp overlap

RCOR1 1 dataset

ChIP keratinocyte_diff GSE57702.RCOR1.keratinocyte_diff 192 bp overlap

RNF2 4 datasets

ChIP H1 ENCFF239FFS 331 bp overlap

ChIP H1 ENCFF239FFS 131 bp overlap

ChIP WA01 ENCSR784VUY.RNF2.WA01 218 bp overlap

ChIP WA09_heat-shock GSE105028.RNF2.WA09_heat-shock 608 bp overlap

ChIP HCC70 GSE126380.RORC.HCC70 350 bp overlap

SALL3 1 dataset

ChIP hiPSC GSE104863.SALL3.hiPSC 84 bp overlap

SAP30 1 dataset

ChIP WA01 ENCSR000ATR.SAP30.WA01 459 bp overlap

SIN3A 4 datasets

ChIP WA01 ENCSR000EBO.SIN3A.WA01 215 bp overlap

ChIP WA01 ENCSR000BIS.SIN3A.WA01 114 bp overlap

ChIP hiPSC_IA12 GSE106870.SIN3A.hiPSC_IA12 162 bp overlap

ChIP hiPSC_IID12 GSE106870.SIN3A.hiPSC_IID12 162 bp overlap

SMAD1 1 dataset

ChIP Hep-G2 ENCSR213QOZ.SMAD1.Hep-G2 220 bp overlap

SMAD2-3 1 dataset

ChIP HUES-8_DE_ctrl GSE109524.SMAD2-3.HUES-8_DE_ctrl 508 bp overlap

SMAD2_3 2 datasets

ChIP DE_D1 S07-DE-d1-SMAD2_3-exp1 340 bp overlap

ChIP DE_D1 S39-DE-d1-SMAD2_3-exp2 280 bp overlap

SMAD3 1 dataset

ChIP BG03_DIFF_2H GSE36578.SMAD3.BG03_DIFF_2H 272 bp overlap

SMARCA4 2 datasets

ChIP Aska-SS GSE108025.SMARCA4.Aska-SS 295 bp overlap

ChIP hiPSC GSE124903.SMARCA4.hiPSC 257 bp overlap

SNAI2 1 dataset

ChIP keratinocyte_LacZ GSE55421.SNAI2.keratinocyte_LacZ 257 bp overlap

SOX2 3 datasets

ChIP KYSE-70 GSE46837.SOX2.KYSE-70 122 bp overlap

ChIP hESC GSE18292.SOX2.hESC 133 bp overlap

ChIP hiPSC GSE56567.SOX2.hiPSC 338 bp overlap

ChIP H1 ENCFF263FUH 279 bp overlap

ChIP WA01 ENCSR000BIR.SP1.WA01 254 bp overlap

SUZ12 8 datasets

ChIP GM12878 ENCFF498QAM 91 bp overlap

ChIP GM12878 ENCSR091BOQ.SUZ12.GM12878 105 bp overlap

ChIP H1 ENCFF881NFR 141 bp overlap

ChIP H1 ENCFF881NFR 141 bp overlap

ChIP K-562 ENCSR000AUC.SUZ12.K-562 79 bp overlap

ChIP NT2-D1 ENCSR000EXH.SUZ12.NT2-D1 186 bp overlap

ChIP NT2/D1 ENCFF574SXS 521 bp overlap

ChIP WA01 ENCSR000ATS.SUZ12.WA01 424 bp overlap

ChIP H9_MESODERM GSE60606.T.H9_MESODERM 335 bp overlap

ChIP HepG2 ENCFF811TLA 162 bp overlap

ChIP NPC GSE154479.TCF3.NPC 225 bp overlap

TEAD1 1 dataset

ChIP pancreas_12D ERP008682.TEAD1.pancreas_12D 187 bp overlap

TEAD4 4 datasets

ChIP ESC S26-ESC-d0-TEAD4-exp1 387 bp overlap

ChIP H1 ENCFF778PAX 82 bp overlap

ChIP Ishikawa ENCSR000BSW.TEAD4.Ishikawa 134 bp overlap

ChIP hESC GSE99202.TEAD4.hESC 235 bp overlap

TFAP2C 2 datasets

ChIP UCLA1-hESCs_TFAP2C--_1d_TFAP2C_Induc GSE101074.TFAP2C.UCLA1-hESCs_TFAP2C--_1d_TFAP2C_Induc 608 bp overlap

ChIP UCLA1-hESCs_TFAP2C--_2d_TFAP2C_Induc GSE101074.TFAP2C.UCLA1-hESCs_TFAP2C--_2d_TFAP2C_Induc 428 bp overlap

TGIF2 1 dataset

ChIP WTC11 ENCFF649SHI 135 bp overlap

ChIP Calu-1_MUT8-COMB GSE128673.TP53.Calu-1_MUT8-COMB 277 bp overlap

ChIP NT2-D1 ENCSR000EXG.YY1.NT2-D1 125 bp overlap

ZFP91 1 dataset

ChIP HepG2 ENCFF012CME 257 bp overlap

ZNF160 1 dataset

ChIP HepG2 ENCFF091XHU 249 bp overlap

ZNF207 1 dataset

ChIP WA09 GSE118632.ZNF207.WA09 234 bp overlap

ZNF221 1 dataset

ChIP HepG2 ENCFF374BUN 519 bp overlap

ZNF274 1 dataset

ChIP Hep-G2 ENCSR871VNN.ZNF274.Hep-G2 164 bp overlap

ZNF407 1 dataset

ChIP Hep-G2 ENCSR005WGY.ZNF407.Hep-G2 101 bp overlap

ZNF548 1 dataset

ChIP HepG2 ENCFF586TZH 233 bp overlap

ZNF550 1 dataset

ChIP Hep-G2 ENCSR198BHH.ZNF550.Hep-G2 167 bp overlap

ZNF556 1 dataset

ChIP HepG2 ENCFF008WIK 194 bp overlap

ZNF574 1 dataset

ChIP HepG2 ENCFF206MMY 84 bp overlap

ZNF576 1 dataset

ChIP HepG2 ENCFF157BAG 224 bp overlap

ZNF605 1 dataset

ChIP HepG2 ENCFF640NFJ 560 bp overlap

ZNF788P 1 dataset

ChIP HepG2 ENCFF689IBZ 423 bp overlap

ZNF800 1 dataset

ChIP Hep-G2 ENCSR701WPG.ZNF800.Hep-G2 150 bp overlap

ZNF883 1 dataset

ChIP Hep-G2 ENCSR882YYL.ZNF883.Hep-G2 215 bp overlap