CEBPB

CEBPB

CCAAT enhancer binding protein beta | C/EBP-beta, CRP2, IL6DBP, LAP, NFIL6, TCF5

This intronless gene encodes a transcription factor that contains a basic leucine zipper (bZIP) domain. The encoded protein functions as a homodimer but can also form heterodimers with CCAAT/enhancer-binding proteins alpha, delta, and gamma. Activity of this protein is important in the regulation of genes involved in immune and inflammatory responses, among other processes. The use of alternative in-frame AUG start codons results in multiple protein isoforms, each with distinct biological functions. [provided by RefSeq, Oct 2013]

Developmental clusters: GC3

Biological processes 109 terms

CHOP-C/EBP complex (GO:0036488)CHOP-C/EBP complex (GO:0036488)DNA binding (GO:0003677)DNA binding (GO:0003677)DNA-binding transcription activator activity, RNA polymerase II-specific (GO:0001228)DNA-binding transcription factor activity (GO:0003700)DNA-binding transcription factor activity (GO:0003700)DNA-binding transcription factor activity, RNA polymerase II-specific (GO:0000981)DNA-binding transcription factor activity, RNA polymerase II-specific (GO:0000981)DNA-binding transcription factor activity, RNA polymerase II-specific (GO:0000981)DNA-binding transcription factor activity, RNA polymerase II-specific (GO:0000981)DNA-binding transcription factor binding (GO:0140297)DNA-binding transcription repressor activity, RNA polymerase II-specific (GO:0001227)DNA-binding transcription repressor activity, RNA polymerase II-specific (GO:0001227)DNA-templated transcription (GO:0006351)RNA polymerase II cis-regulatory region sequence-specific DNA binding (GO:0000978)RNA polymerase II cis-regulatory region sequence-specific DNA binding (GO:0000978)RNA polymerase II cis-regulatory region sequence-specific DNA binding (GO:0000978)RNA polymerase II core promoter sequence-specific DNA binding (GO:0000979)RNA polymerase II transcription regulator complex (GO:0090575)RNA polymerase II transcription regulatory region sequence-specific DNA binding (GO:0000977)RNA polymerase II-specific DNA-binding transcription factor binding (GO:0061629)T-helper 1 cell activation (GO:0035711)acute-phase response (GO:0006953)brown fat cell differentiation (GO:0050873)cellular response to interleukin-1 (GO:0071347)cellular response to lipopolysaccharide (GO:0071222)chromatin (GO:0000785)chromatin (GO:0000785)chromatin DNA binding (GO:0031490)chromatin binding (GO:0003682)condensed chromosome, centromeric region (GO:0000779)cytoplasm (GO:0005737)defense response to bacterium (GO:0042742)defense response to bacterium (GO:0042742)granuloma formation (GO:0002432)hepatocyte proliferation (GO:0072574)hepatocyte proliferation (GO:0072574)histone acetyltransferase binding (GO:0035035)histone deacetylase binding (GO:0042826)identical protein binding (GO:0042802)immune response (GO:0006955)inflammatory response (GO:0006954)integrated stress response signaling (GO:0140467)intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress (GO:0070059)intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress (GO:0070059)kinase binding (GO:0019900)liver development (GO:0001889)liver regeneration (GO:0097421)liver regeneration (GO:0097421)memory (GO:0007613)myeloid cell development (GO:0061515)negative regulation of T cell proliferation (GO:0042130)negative regulation of T cell proliferation (GO:0042130)negative regulation of transcription by RNA polymerase II (GO:0000122)negative regulation of transcription by RNA polymerase II (GO:0000122)nuclear glucocorticoid receptor binding (GO:0035259)nuclear matrix (GO:0016363)nucleoplasm (GO:0005654)nucleoplasm (GO:0005654)nucleus (GO:0005634)nucleus (GO:0005634)nucleus (GO:0005634)nucleus (GO:0005634)nucleus (GO:0005634)ovarian follicle development (GO:0001541)ovarian follicle development (GO:0001541)positive regulation of DNA-templated transcription (GO:0045893)positive regulation of DNA-templated transcription (GO:0045893)positive regulation of biomineral tissue development (GO:0070169)positive regulation of biomineral tissue development (GO:0070169)positive regulation of cold-induced thermogenesis (GO:0120162)positive regulation of cold-induced thermogenesis (GO:0120162)positive regulation of fat cell differentiation (GO:0045600)positive regulation of fat cell differentiation (GO:0045600)positive regulation of gene expression (GO:0010628)positive regulation of inflammatory response (GO:0050729)positive regulation of interleukin-4 production (GO:0032753)positive regulation of interleukin-4 production (GO:0032753)positive regulation of sodium-dependent phosphate transport (GO:2000120)positive regulation of sodium-dependent phosphate transport (GO:2000120)positive regulation of transcription by RNA polymerase II (GO:0045944)positive regulation of transcription by RNA polymerase II (GO:0045944)positive regulation of transcription by RNA polymerase II (GO:0045944)positive regulation of transcription by RNA polymerase II (GO:0045944)protein binding (GO:0005515)protein heterodimerization activity (GO:0046982)protein homodimerization activity (GO:0042803)protein homodimerization activity (GO:0042803)regulation of DNA-templated transcription (GO:0006355)regulation of DNA-templated transcription (GO:0006355)regulation of cell differentiation (GO:0045595)regulation of dendritic cell differentiation (GO:2001198)regulation of odontoblast differentiation (GO:1901329)regulation of odontoblast differentiation (GO:1901329)regulation of osteoclast differentiation (GO:0045670)regulation of osteoclast differentiation (GO:0045670)regulation of transcription by RNA polymerase II (GO:0006357)regulation of transcription by RNA polymerase II (GO:0006357)regulation of transcription by RNA polymerase II (GO:0006357)regulation of transcription by RNA polymerase II (GO:0006357)regulation of transcription by RNA polymerase II (GO:0006357)response to endoplasmic reticulum stress (GO:0034976)response to lipopolysaccharide (GO:0032496)sequence-specific DNA binding (GO:0043565)sequence-specific double-stranded DNA binding (GO:1990837)transcription cis-regulatory region binding (GO:0000976)transcription cis-regulatory region binding (GO:0000976)ubiquitin-like protein ligase binding (GO:0044389)

Expression (TPM)

TFs regulating CEBPB 0 TFs

Transcription factors with Perturb-seq knockdown data for CEBPB. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = CEBPB upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.

TF	Mean coef	Binding	Outlier	TF→Gene link

Rows:

Elements linked to CEBPB

Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of CEBPB, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.

Accessibility	Element	Dist. to TSS	Link type	TFs
	chr20:49,915,234–49,916,043	275.2 kb	Distal (>10kb) Multiome	965
	chr20:49,936,000–49,936,835	254.5 kb	Distal (>10kb) Multiome	878
	chr20:49,979,039–49,979,667	211.5 kb	Distal (>10kb) Multiome	832
	chr20:49,982,091–49,984,748	208.0 kb	Distal (>10kb) Multiome	1116
	chr20:50,112,672–50,113,319	77.7 kb	Distal (>10kb) Multiome	839
	chr20:50,153,404–50,154,338	37.0 kb	Distal (>10kb) Multiome	1028
	chr20:50,165,812–50,166,377	24.7 kb	Distal (>10kb) Multiome	1037
	chr20:50,171,676–50,172,948	18.4 kb	Distal (>10kb) Multiome	821
	chr20:50,186,295–50,186,528	4.3 kb	Proximal (<10kb)	498
	chr20:50,189,686–50,192,514	345 bp	At TSS Multiome	1125
	chr20:50,194,979–50,195,626	4.2 kb	Proximal (<10kb)	299
	chr20:50,321,165–50,321,654	130.6 kb	Distal (>10kb) Multiome HiCAR	683

Genome Browser

Genomic view of the CEBPB locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.