METTL22

methyltransferase 22, Kin17 lysine | FLJ12433, MGC2654, C16orf68

This gene encodes a member of the non-histone lysine methyltransferases. It interacts with its substrate, Kin17, which is involved in DNA repair and replication and mRNA processing. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2016]

Biological processes 16 terms

heat shock protein binding (GO:0031072)nucleolus (GO:0005730)nucleoplasm (GO:0005654)nucleoplasm (GO:0005654)nucleus (GO:0005634)nucleus (GO:0005634)nucleus (GO:0005634)protein binding (GO:0005515)protein methylation (GO:0006479)protein methyltransferase activity (GO:0008276)protein methyltransferase activity (GO:0008276)protein-containing complex (GO:0032991)protein-containing complex (GO:0032991)protein-lysine N-methyltransferase activity (GO:0016279)protein-lysine N-methyltransferase activity (GO:0016279)protein-lysine N-methyltransferase activity (GO:0016279)

Expression (TPM)

TFs regulating METTL22 0 TFs

Transcription factors with Perturb-seq knockdown data for METTL22. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = METTL22 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.

TF	Mean coef	Binding	Outlier	TF→Gene link

Rows:

Elements linked to METTL22

Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of METTL22, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.

Element	Dist. to TSS	Link type	TFs
chr16:8,565,417–8,565,961	56.0 kb	Distal (>10kb) Multiome	155
chr16:8,567,546–8,568,044	53.8 kb	Distal (>10kb) Multiome	605
chr16:8,588,655–8,589,263	32.8 kb	Distal (>10kb) Multiome	96
chr16:8,621,400–8,622,171	13 bp	At TSS Multiome	736
chr16:8,622,297–8,622,565	615 bp	At TSS	163
chr16:8,660,694–8,661,275	39.4 kb	Distal (>10kb) Multiome	325
chr16:8,673,966–8,674,850	52.8 kb	Distal (>10kb) Multiome	585
chr16:8,797,340–8,798,108	176.1 kb	Distal (>10kb) Multiome	1028
chr16:8,831,534–8,832,572	210.5 kb	Distal (>10kb) Multiome	184
chr16:8,866,241–8,867,974	245.0 kb	Distal (>10kb) Multiome	680
chr16:8,868,171–8,869,530	247.4 kb	Distal (>10kb) Multiome	934

Genome Browser

Genomic view of the METTL22 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.