Predicted to enable DNA-binding transcription activator activity, RNA polymerase II-specific; RNA polymerase II cis-regulatory region sequence-specific DNA binding activity; and promoter-specific chromatin binding activity. Predicted to be involved in positive regulation of transcription by RNA polymerase II; regulation of signal transduction; and regulation of stem cell division. Located in nuclear body. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for PRDM15. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = PRDM15 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of PRDM15, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr21:41,678,592–41,679,284 | 200.3 kb | Distal (>10kb) Multiome | 586 | |
| chr21:41,766,154–41,767,269 | 112.3 kb | Distal (>10kb) Multiome | 579 | |
| chr21:41,778,087–41,778,564 | 101.0 kb | Distal (>10kb) Multiome | 367 | |
| chr21:41,878,502–41,879,847 | 173 bp | At TSS Multiome | 630 | |
| chr21:41,953,094–41,954,549 | 74.7 kb | Distal (>10kb) Multiome | 667 | |
| chr21:42,009,116–42,011,396 | 130.9 kb | Distal (>10kb) Multiome | 954 | |
| chr21:42,107,454–42,108,282 | 228.6 kb | Distal (>10kb) Multiome HiCAR | 336 |
Genomic view of the PRDM15 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.