ZNF574

zinc finger protein 574 | FLJ22059

Predicted to enable DNA binding activity and zinc ion binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be active in nucleus. [provided by Alliance of Genome Resources, Jul 2025]

Biological processes 13 terms

cytoplasm (GO:0005737)cytoplasm (GO:0005737)cytosolic ribosome assembly (GO:0042256)developmental process (GO:0032502)nucleus (GO:0005634)nucleus (GO:0005634)nucleus (GO:0005634)protein binding (GO:0005515)regulation of ribosome biogenesis (GO:0090069)regulation of transcription by RNA polymerase II (GO:0006357)ribosomal large subunit binding (GO:0043023)ribosome-associated ubiquitin-dependent protein catabolic process (GO:1990116)transcription cis-regulatory region binding (GO:0000976)

Expression (TPM)

TFs regulating ZNF574 0 TFs

Transcription factors with Perturb-seq knockdown data for ZNF574. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ZNF574 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.

TF	Mean coef	Binding	Outlier	TF→Gene link

Rows:

Elements linked to ZNF574

Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ZNF574, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.

Element	Dist. to TSS	Link type	TFs
chr19:41,859,455–41,860,753	216.3 kb	Distal (>10kb) Multiome	1018
chr19:41,883,883–41,884,651	191.9 kb	Distal (>10kb) Multiome	917
chr19:41,887,651–41,888,254	188.2 kb	Distal (>10kb) Multiome	553
chr19:41,927,700–41,928,620	148.0 kb	Distal (>10kb) Multiome	277
chr19:41,930,462–41,931,200	145.2 kb	Distal (>10kb) Multiome	147
chr19:41,957,648–41,959,799	117.6 kb	Distal (>10kb) Multiome	839
chr19:41,993,779–41,994,412	82.0 kb	Distal (>10kb) Multiome	360
chr19:41,998,577–41,999,349	77.3 kb	Distal (>10kb) Multiome	292
chr19:42,075,557–42,076,657	130 bp	At TSS Multiome	846
chr19:42,095,735–42,096,278	19.9 kb	Distal (>10kb) Multiome	107
chr19:42,132,949–42,133,545	57.1 kb	Distal (>10kb) Multiome	447
chr19:42,176,787–42,177,398	101.0 kb	Distal (>10kb) Multiome	381
chr19:42,216,521–42,218,719	141.6 kb	Distal (>10kb) Multiome	841
chr19:42,219,693–42,220,678	144.1 kb	Distal (>10kb) Multiome	735
chr19:42,241,985–42,243,820	166.8 kb	Distal (>10kb) Multiome	891
chr19:42,244,086–42,245,258	168.7 kb	Distal (>10kb) Multiome	768
chr19:42,253,030–42,256,178	177.7 kb	Distal (>10kb) Multiome	900
chr19:42,267,812–42,269,463	192.7 kb	Distal (>10kb) Multiome	887
chr19:42,279,620–42,280,909	203.9 kb	Distal (>10kb) Multiome	818
chr19:42,283,173–42,285,280	207.9 kb	Distal (>10kb) Multiome	739
chr19:42,301,842–42,303,114	226.4 kb	Distal (>10kb) Multiome	858
chr19:42,313,206–42,313,892	237.4 kb	Distal (>10kb) Multiome	515
chr19:42,323,530–42,326,402	249.3 kb	Distal (>10kb) Multiome	833

Genome Browser

Genomic view of the ZNF574 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.