This gene encodes a protein with sequence similarity to retinoblastoma-binding protein-1. The encoded protein is a subunit of the histone deacetylase-dependant SIN3A transcriptional corepressor complex, which functions in diverse cellular processes including proliferation, differentiation, apoptosis, oncogenesis, and cell fate determination. The gene product is recognized by IgG antibody isolated from a breast cancer patient and appears to be a molecular marker associated with a broad range of human malignancies. Alternate transcriptional splice variants encoding different isoforms have been characterized. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for ARID4B. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ARID4B upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ARID4B, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr1:235,093,150–235,094,131 | 234.4 kb | Distal (>10kb) Multiome | 491 | |
| chr1:235,128,387–235,130,613 | 198.1 kb | Distal (>10kb) Multiome | 1042 | |
| chr1:235,160,743–235,162,007 | 166.9 kb | Distal (>10kb) Multiome | 1015 | |
| chr1:235,304,634–235,305,365 | 23.2 kb | Distal (>10kb) Multiome | 220 | |
| chr1:235,326,947–235,329,481 | 350 bp | At TSS Multiome | 1010 | |
| chr1:235,367,126–235,367,788 | 39.2 kb | Distal (>10kb) Multiome | 851 | |
| chr1:235,503,729–235,505,713 | 176.4 kb | Distal (>10kb) Multiome | 1129 | |
| chr1:235,546,455–235,547,226 | 218.6 kb | Distal (>10kb) Multiome | 80 |
Genomic view of the ARID4B locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.