POU2F1

POU class 2 homeobox 1 | OCT1, OTF1

The OCT1 transcription factor was among the first identified members of the POU transcription factor family (summarized by Sturm et al., 1993 [PubMed 8314572]). Members of this family contain the POU domain, a 160-amino acid region necessary for DNA binding to the octameric sequence ATGCAAAT.[supplied by OMIM, Jul 2010]

Member of: DE-2 DE-2.1

Biological processes 29 terms

DNA binding (GO:0003677)DNA binding (GO:0003677)DNA-binding transcription activator activity, RNA polymerase II-specific (GO:0001228)DNA-binding transcription factor activity (GO:0003700)DNA-binding transcription factor activity, RNA polymerase II-specific (GO:0000981)DNA-binding transcription factor activity, RNA polymerase II-specific (GO:0000981)DNA-binding transcription factor activity, RNA polymerase II-specific (GO:0000981)DNA-binding transcription factor activity, RNA polymerase II-specific (GO:0000981)RNA polymerase II cis-regulatory region sequence-specific DNA binding (GO:0000978)RNA polymerase II cis-regulatory region sequence-specific DNA binding (GO:0000978)RNA polymerase II cis-regulatory region sequence-specific DNA binding (GO:0000978)RNA polymerase II core promoter sequence-specific DNA binding (GO:0000979)RNA polymerase II transcription regulator complex (GO:0090575)RNA polymerase II transcription regulator complex (GO:0090575)chromatin (GO:0000785)identical protein binding (GO:0042802)negative regulation of DNA-templated transcription (GO:0045892)negative regulation of DNA-templated transcription (GO:0045892)nucleoplasm (GO:0005654)nucleus (GO:0005634)nucleus (GO:0005634)positive regulation of miRNA transcription (GO:1902895)positive regulation of transcription by RNA polymerase II (GO:0045944)positive regulation of transcription by RNA polymerase II (GO:0045944)positive regulation of transcription by RNA polymerase II (GO:0045944)protein binding (GO:0005515)regulation of DNA-templated transcription (GO:0006355)regulation of transcription by RNA polymerase II (GO:0006357)sequence-specific DNA binding (GO:0043565)

Expression (TPM)

TFs regulating POU2F1 0 TFs

Transcription factors with Perturb-seq knockdown data for POU2F1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = POU2F1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.

TF	Mean coef	Binding	Outlier	TF→Gene link

Rows:

Elements linked to POU2F1

Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of POU2F1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.

Element	Dist. to TSS	Link type	TFs
chr1:166,920,313–166,921,576	300.0 kb	Distal (>10kb) Multiome	206
chr1:166,975,212–166,976,080	245.3 kb	Distal (>10kb) Multiome	470
chr1:167,066,432–167,066,980	154.1 kb	Distal (>10kb) Multiome HiCAR	430
chr1:167,121,335–167,122,028	99.3 kb	Distal (>10kb) Multiome	238
chr1:167,148,291–167,148,891	72.3 kb	Distal (>10kb) Multiome	99
chr1:167,165,942–167,166,725	54.4 kb	Distal (>10kb) Multiome	236
chr1:167,219,764–167,222,585	276 bp	At TSS Multiome	1143
chr1:167,345,001–167,345,700	124.5 kb	Distal (>10kb) Multiome	142
chr1:167,439,212–167,439,960	218.7 kb	Distal (>10kb) Multiome	362
chr1:167,454,695–167,456,365	234.2 kb	Distal (>10kb) Multiome	569
chr1:167,489,386–167,490,223	269.0 kb	Distal (>10kb) Multiome	134

Genome Browser

Genomic view of the POU2F1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.