RORC

RAR related orphan receptor C | NR1F3, RORG, RZRG, TOR

The protein encoded by this gene is a DNA-binding transcription factor and is a member of the NR1 subfamily of nuclear hormone receptors. The specific functions of this protein are not known; however, studies of a similar gene in mice have shown that this gene may be essential for lymphoid organogenesis and may play an important regulatory role in thymopoiesis. In addition, studies in mice suggest that the protein encoded by this gene may inhibit the expression of Fas ligand and IL2. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Biological processes 50 terms

DNA binding (GO:0003677)DNA-binding transcription factor activity (GO:0003700)DNA-binding transcription factor activity (GO:0003700)DNA-binding transcription factor activity, RNA polymerase II-specific (GO:0000981)DNA-binding transcription factor activity, RNA polymerase II-specific (GO:0000981)DNA-binding transcription repressor activity, RNA polymerase II-specific (GO:0001227)Peyer's patch development (GO:0048541)RNA polymerase II cis-regulatory region sequence-specific DNA binding (GO:0000978)RNA polymerase II cis-regulatory region sequence-specific DNA binding (GO:0000978)T-helper 17 cell differentiation (GO:0072539)T-helper cell differentiation (GO:0042093)adipose tissue development (GO:0060612)cellular response to sterol (GO:0036315)chromatin (GO:0000785)circadian regulation of gene expression (GO:0032922)circadian rhythm (GO:0007623)intracellular receptor signaling pathway (GO:0030522)ligand-modulated transcription factor activity (GO:0098531)lymph node development (GO:0048535)negative regulation of thymocyte apoptotic process (GO:0070244)negative regulation of transcription by RNA polymerase II (GO:0000122)nuclear body (GO:0016604)nuclear receptor activity (GO:0004879)nuclear receptor activity (GO:0004879)nuclear receptor activity (GO:0004879)nuclear receptor activity (GO:0004879)nucleoplasm (GO:0005654)nucleoplasm (GO:0005654)nucleus (GO:0005634)nucleus (GO:0005634)nucleus (GO:0005634)nucleus (GO:0005634)oxysterol binding (GO:0008142)oxysterol binding (GO:0008142)positive regulation of DNA-templated transcription (GO:0045893)positive regulation of circadian rhythm (GO:0042753)protein binding (GO:0005515)regulation of DNA-templated transcription (GO:0006355)regulation of fat cell differentiation (GO:0045598)regulation of gene expression (GO:0010468)regulation of glucose metabolic process (GO:0010906)regulation of steroid metabolic process (GO:0019218)regulation of transcription by RNA polymerase II (GO:0006357)regulation of transcription by RNA polymerase II (GO:0006357)regulatory T cell differentiation (GO:0045066)sequence-specific DNA binding (GO:0043565)sequence-specific double-stranded DNA binding (GO:1990837)tolerance induction in gut-associated lymphoid tissue (GO:0002394)xenobiotic metabolic process (GO:0006805)zinc ion binding (GO:0008270)

Expression (TPM)