Predicted to enable DNA-binding transcription factor activity, RNA polymerase II-specific and RNA polymerase II cis-regulatory region sequence-specific DNA binding activity. Predicted to be involved in regulation of transcription by RNA polymerase II. Predicted to be located in nucleus. [provided by Alliance of Genome Resources, Jul 2025]
Transcription factors with Perturb-seq knockdown data for ZNF883. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ZNF883 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ZNF883, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr9:112,717,577–112,718,753 | 294.0 kb | Distal (>10kb) Multiome | 751 | |
| chr9:112,750,159–112,751,980 | 261.5 kb | Distal (>10kb) Multiome | 907 | |
| chr9:112,771,981–112,772,634 | 239.9 kb | Distal (>10kb) Multiome | 89 | |
| chr9:113,011,893–113,012,348 | 36 bp | At TSS Multiome | 444 | |
| chr9:113,056,219–113,057,065 | 44.6 kb | Distal (>10kb) Multiome | 732 | |
| chr9:113,150,622–113,151,556 | 138.8 kb | Distal (>10kb) Multiome | 705 | |
| chr9:113,220,980–113,222,241 | 209.2 kb | Distal (>10kb) Multiome | 819 | |
| chr9:113,274,845–113,275,974 | 263.4 kb | Distal (>10kb) Multiome | 852 |
Genomic view of the ZNF883 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.