HNRNPLL is a master regulator of activation-induced alternative splicing in T cells. In particular, it alters splicing of CD45 (PTPRC; MIM 151460), a tyrosine phosphatase essential for T-cell development and activation (Oberdoerffer et al., 2008 [PubMed 18669861]).[supplied by OMIM, Aug 2008]
Transcription factors with Perturb-seq knockdown data for HNRNPLL. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = HNRNPLL upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of HNRNPLL, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr2:38,376,242–38,378,169 | 225.5 kb | Distal (>10kb) Multiome | 1082 | |
| chr2:38,432,787–38,433,235 | 169.9 kb | Distal (>10kb) Multiome | 614 | |
| chr2:38,440,476–38,441,570 | 162.0 kb | Distal (>10kb) Multiome | 331 | |
| chr2:38,442,985–38,445,041 | 158.3 kb | Distal (>10kb) Multiome | 354 | |
| chr2:38,535,703–38,536,446 | 66.7 kb | Distal (>10kb) Multiome | 711 | |
| chr2:38,542,771–38,543,473 | 59.8 kb | Distal (>10kb) Multiome | 516 | |
| chr2:38,601,968–38,603,924 | 124 bp | At TSS Multiome | 1077 | |
| chr2:38,665,660–38,666,774 | 63.1 kb | Distal (>10kb) Multiome | 828 | |
| chr2:38,750,264–38,752,290 | 148.5 kb | Distal (>10kb) Multiome | 1162 | |
| chr2:38,875,424–38,876,417 | 273.0 kb | Distal (>10kb) Multiome | 853 |
Genomic view of the HNRNPLL locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.