This gene is a member of a phylogenetically conserved family of genes that share a common DNA-binding domain, the T-box. T-box genes encode transcription factors involved in the regulation of developmental processes. This gene product is the human homolog of mouse Tbx2, and shares strong sequence similarity with Drosophila omb protein. Expression studies indicate that this gene may have a potential role in tumorigenesis as an immortalizing agent. Transcript heterogeneity due to alternative polyadenylation has been noted for this gene. [provided by RefSeq, Jul 2008]
Transcription factors with Perturb-seq knockdown data for TBX2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = TBX2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of TBX2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr17:61,389,816–61,390,219 | 9.6 kb | Proximal (<10kb) | 440 | |
| chr17:61,393,625–61,393,850 | 6.0 kb | Proximal (<10kb) | 248 | |
| chr17:61,394,029–61,394,488 | 5.4 kb | Proximal (<10kb) | 497 | |
| chr17:61,395,593–61,397,794 | 2.0 kb | Proximal (<10kb) | 334 | |
| chr17:61,398,963–61,400,696 | at TSS | At TSS | 714 | |
| chr17:61,404,425–61,405,894 | 4.6 kb | Proximal (<10kb) | 178 | |
| chr17:61,409,276–61,409,987 | 9.4 kb | Proximal (<10kb) | 433 |
Genomic view of the TBX2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.