The protein encoded by this gene, a member of the MYB family of transcription factor genes, is a nuclear protein involved in cell cycle progression. The encoded protein is phosphorylated by cyclin A/cyclin-dependent kinase 2 during the S-phase of the cell cycle and possesses both activator and repressor activities. It has been shown to activate the cell division cycle 2, cyclin D1, and insulin-like growth factor-binding protein 5 genes. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2013]
Transcription factors with Perturb-seq knockdown data for MYBL2. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = MYBL2 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of MYBL2, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr20:43,457,127–43,458,915 | 209.4 kb | Distal (>10kb) Multiome | 1116 | |
| chr20:43,507,189–43,508,028 | 159.5 kb | Distal (>10kb) Multiome | 658 | |
| chr20:43,508,294–43,509,032 | 158.2 kb | Distal (>10kb) Multiome | 227 | |
| chr20:43,513,723–43,515,130 | 152.8 kb | Distal (>10kb) Multiome | 700 | |
| chr20:43,590,411–43,591,331 | 76.3 kb | Distal (>10kb) Multiome | 897 | |
| chr20:43,657,233–43,658,086 | 9.6 kb | Proximal (<10kb) Multiome | 995 | |
| chr20:43,666,536–43,667,856 | 90 bp | At TSS Multiome | 852 | |
| chr20:43,732,772–43,733,261 | 66.0 kb | Distal (>10kb) Multiome | 21 | |
| chr20:43,914,353–43,915,171 | 247.7 kb | Distal (>10kb) Multiome | 285 |
Genomic view of the MYBL2 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.