RCOR1

REST corepressor 1 | COREST, KIAA0071, RCOR

This gene encodes a protein that is well-conserved, downregulated at birth, and with a specific role in determining neural cell differentiation. The encoded protein binds to the C-terminal domain of REST (repressor element-1 silencing transcription factor). [provided by RefSeq, Aug 2011]

Member of: DE-2 DE-2.1

Biological processes 22 terms

DNA repair complex (GO:1990391)chromatin binding (GO:0003682)enzyme binding (GO:0019899)erythrocyte differentiation (GO:0030218)histone deacetylase complex (GO:0000118)histone methyltransferase complex (GO:0035097)negative regulation of DNA-templated transcription (GO:0045892)negative regulation of DNA-templated transcription (GO:0045892)negative regulation of DNA-templated transcription (GO:0045892)negative regulation of gene expression (GO:0010629)nucleoplasm (GO:0005654)nucleoplasm (GO:0005654)nucleus (GO:0005634)nucleus (GO:0005634)nucleus (GO:0005634)positive regulation of megakaryocyte differentiation (GO:0045654)protein binding (GO:0005515)regulation of transcription by RNA polymerase II (GO:0006357)transcription corepressor activity (GO:0003714)transcription corepressor activity (GO:0003714)transcription regulator complex (GO:0005667)transcription repressor complex (GO:0017053)

Expression (TPM)

TFs regulating RCOR1 0 TFs

Transcription factors with Perturb-seq knockdown data for RCOR1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = RCOR1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.

TF	Mean coef	Binding	Outlier	TF→Gene link

Rows:

Elements linked to RCOR1

Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of RCOR1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.

Element	Dist. to TSS	Link type	TFs
chr14:102,304,511–102,305,687	287.5 kb	Distal (>10kb) Multiome	568
chr14:102,314,028–102,314,685	278.3 kb	Distal (>10kb) Multiome	720
chr14:102,316,590–102,317,741	275.5 kb	Distal (>10kb) Multiome	885
chr14:102,319,368–102,320,458	272.9 kb	Distal (>10kb) Multiome	675
chr14:102,362,620–102,363,583	229.7 kb	Distal (>10kb) Multiome	705
chr14:102,507,117–102,508,097	85.0 kb	Distal (>10kb) Multiome	100
chr14:102,508,416–102,511,398	82.8 kb	Distal (>10kb) Multiome	778
chr14:102,516,500–102,517,914	75.7 kb	Distal (>10kb) Multiome	694
chr14:102,524,045–102,525,126	67.9 kb	Distal (>10kb) Multiome	817
chr14:102,545,130–102,546,123	46.9 kb	Distal (>10kb) Multiome	458
chr14:102,554,738–102,555,873	37.1 kb	Distal (>10kb) Multiome	280
chr14:102,585,306–102,585,775	7.1 kb	Proximal (<10kb) Multiome	259
chr14:102,590,707–102,590,858	1.8 kb	Proximal (<10kb)	343
chr14:102,591,431–102,593,846	186 bp	At TSS Multiome	895
chr14:102,776,966–102,778,132	184.7 kb	Distal (>10kb) Multiome	446

Genome Browser

Genomic view of the RCOR1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.