The protein encoded by this gene is a Kruppel-related zinc finger protein which is characterized by the presence of an N-terminal repressor domain, the Kruppel-associated box (KRAB). The KRAB domain is a potent repressor of transcription; thus this protein may function in transcription regulation. Multiple transcript variants have been found for this gene. [provided by RefSeq, Apr 2016]
Transcription factors with Perturb-seq knockdown data for ZNF160. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = ZNF160 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of ZNF160, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr19:52,857,376–52,858,206 | 245.7 kb | Distal (>10kb) Multiome | 332 | |
| chr19:52,896,852–52,898,438 | 205.7 kb | Distal (>10kb) Multiome | 488 | |
| chr19:52,922,765–52,923,968 | 180.0 kb | Distal (>10kb) Multiome | 526 | |
| chr19:52,941,909–52,943,216 | 160.7 kb | Distal (>10kb) Multiome | 494 | |
| chr19:52,944,441–52,945,501 | 158.2 kb | Distal (>10kb) Multiome | 238 | |
| chr19:52,945,942–52,946,905 | 156.8 kb | Distal (>10kb) Multiome | 164 | |
| chr19:52,962,371–52,963,594 | 140.4 kb | Distal (>10kb) Multiome | 663 | |
| chr19:52,993,475–52,994,192 | 109.6 kb | Distal (>10kb) Multiome | 160 | |
| chr19:53,027,952–53,028,653 | 74.9 kb | Distal (>10kb) Multiome | 64 | |
| chr19:53,057,924–53,058,784 | 45.0 kb | Distal (>10kb) Multiome | 160 | |
| chr19:53,095,173–53,095,449 | 8.0 kb | Proximal (<10kb) | 47 | |
| chr19:53,102,740–53,104,032 | 144 bp | At TSS Multiome | 634 | |
| chr19:53,158,810–53,159,647 | 55.7 kb | Distal (>10kb) Multiome | 317 | |
| chr19:53,192,722–53,193,557 | 89.9 kb | Distal (>10kb) Multiome | 285 | |
| chr19:53,196,790–53,197,387 | 93.6 kb | Distal (>10kb) Multiome | 329 | |
| chr19:53,254,450–53,255,344 | 151.5 kb | Distal (>10kb) Multiome | 295 | |
| chr19:53,333,122–53,334,368 | 230.2 kb | Distal (>10kb) Multiome | 319 | |
| chr19:53,365,124–53,366,164 | 262.2 kb | Distal (>10kb) Multiome | 346 | |
| chr19:53,394,512–53,395,775 | 291.6 kb | Distal (>10kb) Multiome | 453 |
Genomic view of the ZNF160 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.