This gene encodes a member of the MYC/MAX/MAD network of basic helix-loop-helix leucine zipper transcription factors. The MYC/MAX/MAD transcription factors mediate cellular proliferation, differentiation and apoptosis. The encoded protein antagonizes MYC-mediated transcriptional activation of target genes by competing for the binding partner MAX and recruiting repressor complexes containing histone deacetylases. Mutations in this gene may play a role in acute leukemia, and the encoded protein is a potential tumor suppressor. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Feb 2011]
Transcription factors with Perturb-seq knockdown data for MXD1. The Binding column indicates whether any binding evidence exists for this TF–gene pair (ChIP-seq or motif footprint peaks). The Mean coef is the average Perturb-seq regression coefficient across active gRNAs (positive = MXD1 upregulated upon KD; negative = downregulated). The Outlier column indicates whether this gene is in the top or bottom 5% of all TF knockdown effects.
| TF | Mean coef | Binding | Outlier | TF→Gene link |
|---|
Open chromatin peaks (ATAC-seq) in the genomic neighbourhood of MXD1, linked by TSS proximity or chromatin conformation (Multiome / HiCAR). Each element overlaps at least one TF ChIP-seq binding site — the TFs column shows how many distinct TFs bind that element.
| Accessibility | Element | Dist. to TSS | Link type | TFs |
|---|---|---|---|---|
| chr2:69,642,875–69,644,362 | 271.2 kb | Distal (>10kb) Multiome | 960 | |
| chr2:69,741,315–69,742,479 | 173.1 kb | Distal (>10kb) Multiome | 894 | |
| chr2:69,798,793–69,799,774 | 115.8 kb | Distal (>10kb) Multiome | 417 | |
| chr2:69,829,001–69,830,537 | 85.5 kb | Distal (>10kb) Multiome | 1005 | |
| chr2:69,914,102–69,915,874 | 227 bp | At TSS Multiome | 1112 | |
| chr2:70,084,998–70,085,484 | 170.2 kb | Distal (>10kb) Multiome HiCAR | 345 | |
| chr2:70,086,194–70,088,572 | 172.0 kb | Distal (>10kb) Multiome HiCAR | 1204 | |
| chr2:70,089,216–70,090,447 | 174.7 kb | Distal (>10kb) Multiome HiCAR | 459 | |
| chr2:70,123,128–70,125,445 | 208.5 kb | Distal (>10kb) Multiome | 779 | |
| chr2:70,140,819–70,143,188 | 227.6 kb | Distal (>10kb) Multiome HiCAR | 1260 | |
| chr2:70,190,215–70,191,415 | 275.9 kb | Distal (>10kb) Multiome | 1013 |
Genomic view of the MXD1 locus showing ATAC-seq accessibility and RNA-seq expression across the ESC → DE time course, together with TF binding peaks and element-to-TSS loop connections.