chr4:128,054,858–128,056,003

chr4 : 128,054,858 – 128,056,003

1,145 bp 126 TFs 6 linked genes

This 1.1 kb open chromatin element is linked to 6 target genes and is bound by 126 transcription factors.

Linked Genes

6 genes

Gene	Expression	Dist. to TSS	Distance	Link type
LARP1B		5.3 kb	Proximal	Proximity
MFSD8		89.6 kb	Distal	Multiome
ABHD18		90.3 kb	Distal	Multiome
PLK4		174.7 kb	Distal	Multiome
PGRMC2		232.2 kb	Distal	Multiome
HSPA4L		273.3 kb	Distal	Multiome

Chromatin Accessibility

Genome Browser

Genomic view centred on this element. Tracks include ATAC-seq accessibility, RNA-seq expression, TF binding peaks, and element-to-gene loop arcs across the ESC → DE time course.

Transcription factors with ChIP-seq peak overlap or TOBIAS motif footprint evidence at this element.

TF Binding

126 transcription factors

AEBP2 1 dataset

ChIP HEK293 ENCSR769JRS.AEBP2.HEK293 144 bp overlap

ARID1A 1 dataset

ChIP HAP1 GSE108387.ARID1A.HAP1 407 bp overlap

ASH2L 3 datasets

ChIP H1 ENCFF399KAM 785 bp overlap

ChIP WA01 ENCSR850KIP.ASH2L.WA01 158 bp overlap

ChIP WA01 ENCSR850KIP.ASH2L.WA01 787 bp overlap

ChIP K-562 ENCSR808AKZ.BCOR.K-562 319 bp overlap

CEBPA 1 dataset

Motif DE_12h DE_12h-CEBPA_MA0102.5 10 bp overlap

CHD7 2 datasets

ChIP H1 ENCFF126NLU 430 bp overlap

ChIP WA01 ENCSR000AVA.CHD7.WA01 289 bp overlap

CREB1 2 datasets

ChIP GM23338 ENCFF432ZEW 305 bp overlap

ChIP GM23338 ENCSR214ZAV.CREB1.GM23338 255 bp overlap

ChIP HAP1_clone21_CTCF-CRISPR GSE152721.CTCF.HAP1_clone21_CTCF-CRISPR 200 bp overlap

Cebpa 1 dataset

ChIP BLaER1 ENCFF460KDD 251 bp overlap

ChIP Hep-G2 ENCSR321VGW.ELF1.Hep-G2 136 bp overlap

EOMES 1 dataset

ChIP hESC GSE26097.EOMES.hESC 169 bp overlap

FEZF2 1 dataset

Motif DE_12h DE_12h-FEZF2_MA2341.1 8 bp overlap

FIGLA 1 dataset

Motif DE_12h DE_12h-FIGLA_MA0820.2 6 bp overlap

FOXA2 2 datasets

ChIP DE DE-FOXA2-1 457 bp overlap

ChIP DE DE-FOXA2-2 449 bp overlap

FOXB1 1 dataset

Motif DE_12h DE_12h-FOXB1_MA0845.1 11 bp overlap

FOXN3 2 datasets

Motif DE_12h DE_12h-FOXN3_MA1489.1 8 bp overlap

Motif ES_0h ES_0h-FOXN3_MA1489.1 8 bp overlap

GATA4 2 datasets

ChIP DE DE-GATA4-1 477 bp overlap

ChIP DE DE-GATA4-2 585 bp overlap

GATA6 3 datasets

ChIP DE DE-GATA6-1 488 bp overlap

ChIP DE DE-GATA6-2 616 bp overlap

ChIP DE_D2 S55-DE-d2-GATA6-exp2 469 bp overlap

GLIS2 1 dataset

Motif DE_12h DE_12h-GLIS2_MA0736.1 14 bp overlap

GLIS3 1 dataset

Motif DE_12h DE_12h-GLIS3_MA0737.1 14 bp overlap

GTF2I 1 dataset

ChIP WTC11 ENCFF255XXZ 345 bp overlap

GTF3C2 1 dataset

ChIP H9 GSE94418.GTF3C2.H9 204 bp overlap

Gfi1B 1 dataset

Motif DE_12h DE_12h-Gfi1B_MA0483.2 10 bp overlap

HAND2 2 datasets

Motif DE_12h DE_12h-HAND2_MA1638.2 6 bp overlap

Motif ES_0h ES_0h-HAND2_MA1638.2 6 bp overlap

HDAC2 1 dataset

ChIP H1 ENCFF939VKA 237 bp overlap

HMBOX1 1 dataset

Motif DE_12h DE_12h-HMBOX1_MA0895.2 7 bp overlap

HMGA2 1 dataset

ChIP WTC11 ENCFF535JLP 181 bp overlap

IRF3 2 datasets

Motif DE_12h DE_12h-IRF3_MA1418.2 17 bp overlap

Motif DE_48h DE_48h-IRF3_MA1418.2 17 bp overlap

ChIP DE_D2 S02-DE-d2-JUN-exp1 386 bp overlap

KDM1A 2 datasets

ChIP H1 ENCFF696SGD 505 bp overlap

ChIP H1 ENCFF696SGD 505 bp overlap

MEF2A 1 dataset

Motif DE_12h DE_12h-MEF2A_MA0052.5 10 bp overlap

MEIS1 2 datasets

Motif DE_12h DE_12h-MEIS1_MA0498.3 5 bp overlap

Motif DE_48h DE_48h-MEIS1_MA0498.3 5 bp overlap

MYBL2 1 dataset

ChIP Hep-G2 ENCSR581KCO.MYBL2.Hep-G2 178 bp overlap

Motif DE_48h DE_48h-MYF6_MA0667.1 10 bp overlap

Msgn1 1 dataset

Motif DE_48h DE_48h-Msgn1_MA1524.3 10 bp overlap

NANOG 9 datasets

ChIP GM23338 ENCFF065NZG 311 bp overlap

ChIP H1 ENCFF747ZPQ 241 bp overlap

ChIP HUES-8 GSE109524.NANOG.HUES-8 613 bp overlap

ChIP WA01 ERP004238.NANOG.WA01 183 bp overlap

ChIP WA01 ERP004238.NANOG.WA01 330 bp overlap

ChIP WA01_3IL ERP004238.NANOG.WA01_3IL 1042 bp overlap

ChIP WA09 GSE105028.NANOG.WA09 563 bp overlap

ChIP WA09_heat-shock GSE105028.NANOG.WA09_heat-shock 526 bp overlap

ChIP hESC GSE18292.NANOG.hESC 240 bp overlap

NEUROD1 2 datasets

Motif DE_12h DE_12h-NEUROD1_MA1109.2 8 bp overlap

Motif ES_0h ES_0h-NEUROD1_MA1109.2 8 bp overlap

Neurod2 2 datasets

Motif DE_12h DE_12h-Neurod2_MA0668.3 8 bp overlap

Motif ES_0h ES_0h-Neurod2_MA0668.3 8 bp overlap

Nfatc2 1 dataset

Motif DE_12h DE_12h-Nfatc2_MA0152.3 8 bp overlap

Nr1h3::Rxra 1 dataset

Motif DE_12h DE_12h-Nr1h3Rxra_MA0494.2 16 bp overlap

OLIG2 1 dataset

Motif DE_12h DE_12h-OLIG2_MA0678.1 10 bp overlap

OLIG3 1 dataset

Motif DE_12h DE_12h-OLIG3_MA0827.1 10 bp overlap

Motif DE_12h DE_12h-PBX3_MA1114.2 11 bp overlap

PKNOX1 1 dataset

Motif DE_12h DE_12h-PKNOX1_MA0782.3 10 bp overlap

POU2F1 3 datasets

Motif DE_12h DE_12h-POU2F1_MA0785.2 9 bp overlap

Motif DE_12h DE_12h-POU2F1_MA0785.2 9 bp overlap

Motif ES_0h ES_0h-POU2F1_MA0785.2 9 bp overlap

POU2F1::SOX2 2 datasets

Motif DE_12h DE_12h-POU2F1SOX2_MA1962.1 17 bp overlap

Motif ES_0h ES_0h-POU2F1SOX2_MA1962.1 17 bp overlap

POU2F2 3 datasets

Motif DE_12h DE_12h-POU2F2_MA0507.3 13 bp overlap

Motif DE_12h DE_12h-POU2F2_MA0507.3 13 bp overlap

Motif ES_0h ES_0h-POU2F2_MA0507.3 13 bp overlap

POU2F3 2 datasets

Motif DE_12h DE_12h-POU2F3_MA0627.3 9 bp overlap

Motif ES_0h ES_0h-POU2F3_MA0627.3 9 bp overlap

POU3F1 3 datasets

Motif DE_12h DE_12h-POU3F1_MA0786.2 10 bp overlap

Motif DE_12h DE_12h-POU3F1_MA0786.2 10 bp overlap

Motif ES_0h ES_0h-POU3F1_MA0786.2 10 bp overlap

POU3F2 3 datasets

Motif DE_12h DE_12h-POU3F2_MA0787.1 12 bp overlap

Motif DE_12h DE_12h-POU3F2_MA0787.1 12 bp overlap

Motif ES_0h ES_0h-POU3F2_MA0787.1 12 bp overlap

POU3F3 3 datasets

Motif DE_12h DE_12h-POU3F3_MA0788.1 13 bp overlap

Motif DE_12h DE_12h-POU3F3_MA0788.1 13 bp overlap

Motif ES_0h ES_0h-POU3F3_MA0788.1 13 bp overlap

POU3F4 3 datasets

Motif DE_12h DE_12h-POU3F4_MA0789.1 9 bp overlap

Motif DE_12h DE_12h-POU3F4_MA0789.1 9 bp overlap

Motif ES_0h ES_0h-POU3F4_MA0789.1 9 bp overlap

POU5F1 6 datasets

Motif DE_12h DE_12h-POU5F1_MA1115.2 7 bp overlap

ChIP DE_D1 DED1-OCT4_Batch_II 262 bp overlap

Motif ES_0h ES_0h-POU5F1_MA1115.2 7 bp overlap

ChIP HUES-8 GSE109524.POU5F1.HUES-8 644 bp overlap

ChIP hESC_NAIVE GSE69646.POU5F1.hESC_NAIVE 465 bp overlap

ChIP hESC_PRIMED GSE69646.POU5F1.hESC_PRIMED 479 bp overlap

POU5F1B 3 datasets

Motif DE_12h DE_12h-POU5F1B_MA0792.1 9 bp overlap

Motif DE_12h DE_12h-POU5F1B_MA0792.1 9 bp overlap

Motif ES_0h ES_0h-POU5F1B_MA0792.1 9 bp overlap

PPARA::RXRA 1 dataset

Motif DE_12h DE_12h-PPARARXRA_MA1148.2 17 bp overlap

PRDM12 1 dataset

ChIP HEK293 ENCSR760AAY.PRDM12.HEK293 158 bp overlap

Pou5f1::Sox2 2 datasets

Motif DE_12h DE_12h-Pou5f1Sox2_MA0142.1 15 bp overlap

Motif ES_0h ES_0h-Pou5f1Sox2_MA0142.1 15 bp overlap

Prdm14 2 datasets

Motif DE_12h DE_12h-Prdm14_MA1998.2 8 bp overlap

Motif DE_48h DE_48h-Prdm14_MA1998.2 8 bp overlap

Ptf1A 2 datasets

Motif DE_12h DE_12h-Ptf1A_MA1618.2 9 bp overlap

Motif ES_0h ES_0h-Ptf1A_MA1618.2 9 bp overlap

RAD21 2 datasets

ChIP HAP1 GSE152721.RAD21.HAP1 520 bp overlap

ChIP HAP1_CTCF GSE126634.RAD21.HAP1_CTCF 299 bp overlap

RBBP5 1 dataset

ChIP WA01 ENCSR000AQC.RBBP5.WA01 204 bp overlap

Motif DE_12h DE_12h-RBPJ_MA1116.2 6 bp overlap

Motif DE_12h DE_12h-RELA_MA0107.1 10 bp overlap

REST 2 datasets

Motif DE_12h DE_12h-REST_MA0138.3 20 bp overlap

ChIP HEK293 ENCSR896UBV.REST.HEK293 181 bp overlap

Motif DE_12h DE_12h-Rarg_MA0860.1 17 bp overlap

SMARCA4 3 datasets

ChIP WA09_heat-shock GSE105028.SMARCA4.WA09_heat-shock 224 bp overlap

ChIP hiPSC GSE124903.SMARCA4.hiPSC 475 bp overlap

ChIP hiPSC_WT GSE124903.SMARCA4.hiPSC_WT 455 bp overlap

SMARCB1 2 datasets

ChIP hiPSC GSE124903.SMARCB1.hiPSC 403 bp overlap

ChIP hiPSC_WT GSE124903.SMARCB1.hiPSC_WT 226 bp overlap

SMARCC1 2 datasets

ChIP hiPSC GSE124903.SMARCC1.hiPSC 254 bp overlap

ChIP hiPSC_WT GSE124903.SMARCC1.hiPSC_WT 378 bp overlap

SOX10 1 dataset

Motif DE_12h DE_12h-SOX10_MA0442.3 6 bp overlap

SOX15 1 dataset

Motif DE_48h DE_48h-SOX15_MA1152.2 7 bp overlap

SOX17 1 dataset

ChIP DE_D2 DED2-SOX17_Batch_II 406 bp overlap

SOX17_M 1 dataset

ChIP DE_D2 DED2-SOX17-M_Batch_II 606 bp overlap

SOX2 2 datasets

ChIP hESC GSE18292.SOX2.hESC 186 bp overlap

ChIP hiPSC GSE56567.SOX2.hiPSC 404 bp overlap

ChIP H1 ENCFF263FUH 321 bp overlap

ChIP WA01 ENCSR000BIR.SP1.WA01 150 bp overlap

SREBF1 1 dataset

Motif DE_12h DE_12h-SREBF1_MA0829.3 10 bp overlap

SREBF2 1 dataset

Motif DE_12h DE_12h-SREBF2_MA0828.3 10 bp overlap

Motif DE_12h DE_12h-SRF_MA0083.3 16 bp overlap

Sox6 2 datasets

Motif DE_12h DE_12h-Sox6_MA0515.1 10 bp overlap

Motif DE_48h DE_48h-Sox6_MA0515.1 10 bp overlap

Stat2 1 dataset

Motif DE_12h DE_12h-Stat2_MA1623.2 10 bp overlap

ChIP WA01 ENCSR000BHO.TAF1.WA01 120 bp overlap

ChIP hESC GSE122298.TBP.hESC 135 bp overlap

ChIP hESC_2h GSE122298.TBP.hESC_2h 120 bp overlap

ChIP hESC_2h GSE122298.TBP.hESC_2h 120 bp overlap

ChIP NPC GSE154479.TCF3.NPC 224 bp overlap

TEAD4 2 datasets

ChIP ESC S26-ESC-d0-TEAD4-exp1 347 bp overlap

ChIP H1 ENCFF778PAX 245 bp overlap

Motif DE_12h DE_12h-THRA_MA1969.2 18 bp overlap

Motif DE_12h DE_12h-THRB_MA1576.2 18 bp overlap

ChIP H9_ectoderm GSE142050.TP53.H9_ectoderm 290 bp overlap

TRIM28 1 dataset

ChIP hESC GSE115387.TRIM28.hESC 311 bp overlap

VEZF1 2 datasets

Motif DE_12h DE_12h-VEZF1_MA1578.2 6 bp overlap

Motif ES_0h ES_0h-VEZF1_MA1578.2 6 bp overlap

ZBTB11 2 datasets

ChIP HEK293 ENCFF262GZJ 120 bp overlap

ChIP HEK293 ENCSR882ZTS.ZBTB11.HEK293 170 bp overlap

ZBTB21 1 dataset

ChIP HEK293 ENCSR321MSF.ZBTB21.HEK293 134 bp overlap

ZBTB6 1 dataset

Motif DE_12h DE_12h-ZBTB6_MA1581.2 9 bp overlap

ZBTB8A 2 datasets

ChIP HEK293 ENCFF303WRD 79 bp overlap

ChIP HEK293 ENCSR481FEC.ZBTB8A.HEK293 198 bp overlap

ZC3H11A 2 datasets

ChIP A-549 ENCSR277OOQ.ZC3H11A.A-549 206 bp overlap

ChIP A549 ENCFF640AQE 152 bp overlap

Motif DE_12h DE_12h-ZEB1_MA0103.4 6 bp overlap

ZFP14 1 dataset

Motif DE_12h DE_12h-ZFP14_MA1972.1 15 bp overlap

ZFP64 1 dataset

ChIP HEK293 ENCSR592KSP.ZFP64.HEK293 160 bp overlap

ZNF101 1 dataset

ChIP HEK293 ENCSR462FWS.ZNF101.HEK293 206 bp overlap

ZNF140 2 datasets

ChIP HEK293 ENCFF501RUF 164 bp overlap

ChIP HEK293 ENCSR464KFG.ZNF140.HEK293 151 bp overlap

ZNF189 1 dataset

ChIP HEK293 ENCSR163RYW.ZNF189.HEK293 190 bp overlap

ZNF19 1 dataset

ChIP HEK293 ENCSR811JJM.ZNF19.HEK293 193 bp overlap

ZNF213 4 datasets

Motif DE_12h DE_12h-ZNF213_MA2121.1 12 bp overlap

Motif DE_12h DE_12h-ZNF213_MA2121.1 12 bp overlap

Motif DE_12h DE_12h-ZNF213_MA2121.1 12 bp overlap

ChIP HEK293 ENCSR295GRB.ZNF213.HEK293 150 bp overlap

ZNF266 1 dataset

ChIP HEK293 ENCSR466VYP.ZNF266.HEK293 181 bp overlap

ZNF34 2 datasets

ChIP HEK293 ENCFF481TFV 154 bp overlap

ChIP HEK293 ENCSR727PIC.ZNF34.HEK293 199 bp overlap

ZNF354A 3 datasets

Motif DE_12h DE_12h-ZNF354A_MA1978.2 20 bp overlap

Motif DE_12h DE_12h-ZNF354A_MA1978.2 20 bp overlap

Motif ES_0h ES_0h-ZNF354A_MA1978.2 20 bp overlap

ZNF366 1 dataset

ChIP HEK293 ENCSR106EBH.ZNF366.HEK293 162 bp overlap

ZNF384 1 dataset

Motif DE_12h DE_12h-ZNF384_MA1125.2 8 bp overlap

ZNF394 2 datasets

ChIP HEK293 ENCFF236OPX 90 bp overlap

ChIP HEK293 ENCSR125DNC.ZNF394.HEK293 231 bp overlap

ZNF426 2 datasets

ChIP HEK293 ENCFF957XYN 202 bp overlap

ChIP HEK293 ENCSR224NFP.ZNF426.HEK293 255 bp overlap

ZNF433 1 dataset

ChIP HEK293 ENCSR586BRJ.ZNF433.HEK293 130 bp overlap

ZNF460 1 dataset

Motif DE_12h DE_12h-ZNF460_MA1596.1 16 bp overlap

ZNF501 1 dataset

ChIP HEK293 ENCSR461ZJT.ZNF501.HEK293 206 bp overlap

ZNF518A 2 datasets

ChIP HEK293 ENCFF892ULS 150 bp overlap

ChIP HEK293 ENCSR159GFL.ZNF518A.HEK293 199 bp overlap

ZNF547 1 dataset

ChIP HEK293 ENCSR909TSW.ZNF547.HEK293 260 bp overlap

ZNF555 2 datasets

ChIP HEK293 ENCFF406QFI 81 bp overlap

ChIP HEK293 ENCSR767XSF.ZNF555.HEK293 168 bp overlap

ZNF558 2 datasets

ChIP HEK293 ENCFF994JWH 163 bp overlap

ChIP HEK293 ENCSR447ZTA.ZNF558.HEK293 186 bp overlap

ZNF577 1 dataset

ChIP HEK293 ENCSR776MDR.ZNF577.HEK293 166 bp overlap

ZNF580 1 dataset

ChIP HEK293 ENCSR668HOP.ZNF580.HEK293 115 bp overlap

ZNF623 2 datasets

ChIP HEK293 ENCFF505YHP 107 bp overlap

ChIP HEK293 ENCSR022IZK.ZNF623.HEK293 195 bp overlap

ZNF629 1 dataset

ChIP HEK293 ENCSR351NON.ZNF629.HEK293 182 bp overlap

ZNF654 2 datasets

ChIP HEK293 ENCFF636WIC 186 bp overlap

ChIP HEK293 ENCSR504VDV.ZNF654.HEK293 158 bp overlap

ZNF680 1 dataset

ChIP HEK293 ENCSR307CKC.ZNF680.HEK293 181 bp overlap

ZNF697 1 dataset

ChIP HEK293 ENCSR217QCK.ZNF697.HEK293 240 bp overlap

ZNF740 2 datasets

Motif DE_12h DE_12h-ZNF740_MA0753.3 10 bp overlap

Motif ES_0h ES_0h-ZNF740_MA0753.3 10 bp overlap

ZNF770 2 datasets

ChIP Hep-G2 ENCSR510GKB.ZNF770.Hep-G2 117 bp overlap

ChIP HepG2 ENCFF233UVH 104 bp overlap

ZNF781 1 dataset

ChIP HEK293 ENCSR777YSB.ZNF781.HEK293 259 bp overlap

ChIP HEK293 ENCSR559IOZ.ZXDB.HEK293 177 bp overlap